CAJ | 학술논문

表观基因组在配子发生和早期胚胎发育中经历一个重编程过程。因此，人们认为表观遗传信息不可能代间传递。表观遗传跨代继承表型的出现，说明某些表观遗传标志可能逃脱了重编程。尽管该观点尚存争议，但日益增多的实验证据表明表观遗传记忆确实存在于哺乳动物中。由于表观遗传修饰具有可逆性，表观基因组易受各种环境因子(如化学物质、营养和行为等)的影响而改变。因此，表观基因组提供了跨代传递环境影响的可能机制。文章介绍了表观遗传跨代继承表型的概念，论述了表观遗传重编程和表观遗传信息跨代传递的分子机制，列举了一些环境因子与表观遗传跨代继承性疾病。
표관기인조재배자발생화조기배태발육중경력일개중편정과정。인차，인문인위표관유전신식불가능대간전체。표관유전과대계승표형적출현，설명모사표관유전표지가능도탈료중편정。진관해관점상존쟁의，단일익증다적실험증거표명표관유전기억학실존재우포유동물중。유우표관유전수식구유가역성，표관기인조역수각충배경인자(여화학물질、영양화행위등)적영향이개변。인차，표관기인조제공료과대전체배경영향적가능궤제。문장개소료표관유전과대계승표형적개념，논술료표관유전중편정화표관유전신식과대전체적분자궤제，열거료일사배경인자여표관유전과대계승성질병。
The epigenome undergoes a reprogramming process during gametogenesis and early embryogenesis. Therefore, it is believed that epigenetic information cannot be transmitted across generations. However, the occurrence of epigenetic transgenerational phenotype suggests that certain epigenetic marks may escape reprogramming. Although the existence of such a mode of inheritance has been controversial, there is increasing evidence that epigenetic memory does occur in mammals. Due to the reversibility of epigenetic modification, the epigenome is easily changed by a variety of environmen-tal factors, such as chemicals, nutrition and behaviour. Therefore, it provides a potential mechanism for the transgenerational transmission of the impact of environmental factors. The purpose of this review is to introduce the concept of epigenetic transgenerational phenotype, to discuss the epigenetic reprogramming and the molecular mechanism of epi-genetic transgenerational transmission, and to list some environmental factors that are associated with epigenetic transgenerational diseases.