CAJ | 학술논문

目的：优化复方葛根经皮给药系统的制剂处方，确定最佳制备工艺。方法：采用单因素试验确定以流涎法制作骨架型复方葛根经皮给药系统的最佳制备工艺。采用均匀实验设计，以葛根素、川芎嗪和丹参酮ⅡA的24 h累积体外透皮总量和透皮速率为考察指标优选复方葛根透皮贴剂的最佳处方。结果：确定制剂处方中含量分别为PVA4.41%、PVP 31.30%、甘油2.16%、压敏胶3.63%、氮酮5.09%、丙二醇2.50%。最佳制备工艺为基质混合加10倍水搅拌均匀，药物以10倍量80%乙醇溶解，与上述基质混合均匀，以流涎法制备贴剂。结论：该制备工艺科学合理，质量稳定，是复方葛根透皮贴剂的最佳制备工艺。
목적：우화복방갈근경피급약계통적제제처방，학정최가제비공예。방법：채용단인소시험학정이류연법제작골가형복방갈근경피급약계통적최가제비공예。채용균균실험설계，이갈근소、천궁진화단삼동ⅡA적24 h루적체외투피총량화투피속솔위고찰지표우선복방갈근투피첩제적최가처방。결과：학정제제처방중함량분별위PVA4.41%、PVP 31.30%、감유2.16%、압민효3.63%、담동5.09%、병이순2.50%。최가제비공예위기질혼합가10배수교반균균，약물이10배량80%을순용해，여상술기질혼합균균，이류연법제비첩제。결론：해제비공예과학합리，질량은정，시복방갈근투피첩제적최가제비공예。
Objective:To optimize the TDDS of Compound Pueraia, and determin the best preparation process. Methods Using single factor experiment to deteimin the best prepation process of TDDS of the skeletal compound pueraia that was made by the salivation method. According to 24h the total cumulative transdermal and penetration rate of Puerarin, ligustrazine and tanshinoneⅡA, by uniform design of experiment, choose the optimal prescription. Results The contents of prescription is 4.41%PVA, 31.30%PVP, 2.16%glycerin, 3.63%PSA, 5.09%Arzone, 2.50%propanediol. The optimal prescription is hybrid stroma stired well with 10 times water of it, 10 times 80%alcohol for drug and mixed with stoma, then prepared patch by the salivation method. Conclusion The optimal preparation process of compound puerarin transdermal patches is rational, scientific and stable quality.