CAJ | 학술논문

复发转移是导致绝大多数肝癌患者术后死亡的主要原因。现有的研究提示，从原发灶或转移灶释放进入血液的循环肿瘤细胞（circulating tumor cells，CTCs）是肝癌根治性术后复发转移的一个主要根源。在过去的10多年中，尽管CTCs检测技术及其临床意义的研究取得了长足进步，但由于缺乏可使用的肝癌CTCs检测方法，目前人们对于肝癌CTCs临床重要性的认识远不及其他主要类型的肿瘤。可喜的是，近年来关于肝癌CTCs检测方法及其临床意义的研究报道逐渐增多，并且得到一些有趣的结果。本文着重总结已报道的肝癌CTCs检测方法，综述肝癌CTCs作为肝癌复发转移来源的现有实验证据以及其作为肝癌预后标志物的现有研究结果，并讨论肝癌CTCs临床转化应用需要解决的技术问题。
복발전이시도치절대다수간암환자술후사망적주요원인。현유적연구제시，종원발조혹전이조석방진입혈액적순배종류세포（circulating tumor cells，CTCs）시간암근치성술후복발전이적일개주요근원。재과거적10다년중，진관CTCs검측기술급기림상의의적연구취득료장족진보，단유우결핍가사용적간암CTCs검측방법，목전인문대우간암CTCs림상중요성적인식원불급기타주요류형적종류。가희적시，근년래관우간암CTCs검측방법급기림상의의적연구보도축점증다，병차득도일사유취적결과。본문착중총결이보도적간암CTCs검측방법，종술간암CTCs작위간암복발전이래원적현유실험증거이급기작위간암예후표지물적현유연구결과，병토론간암CTCs림상전화응용수요해결적기술문제。
Recurrence or metastasis is the major cause of mortality in the patients with hepatocellular carcinoma (HCC) who underwent hepatectomy. Circulating tumor cells (CTCs) disseminated from the primary tumor into the peripheral blood are increasingly recognized as the main source of recurrence and metastasis. In the past decade, with the tremendous progress in the technology of CTC detection, there is convincing evidence that CTCs have great potential as a marker for metastatic disease and poor prognosis in patients with a malignancy. However, probably due to the inability of current commercial methods to capture HCC cells, few studies examining CTC counts have been conducted on HCC patients so far, and knowledge about clinical relevance of CTC detection in HCC is lagging behind other major tumor diseases. Fortunately, some interesting and encouraging results have been recently achieved in the HCC CTC detection, and the situation has started to change for HCC. Here we will outline the different approaches available for HCC CTCs, review clinical studies on CTC detection in HCC patients, and formulate upcoming challenges and technical aspects in this field.