分子诊断与治疗杂志
分子診斷與治療雜誌
분자진단여치료잡지
JOURNAL OF MOLECULAR DIAGNOSIS AND THERAPY
2013年
6期
382-384
,共3页
甲状腺功能亢进症%骨密度%双能X线吸收法
甲狀腺功能亢進癥%骨密度%雙能X線吸收法
갑상선공능항진증%골밀도%쌍능X선흡수법
Hyperthyroidism%Bone density%Dual energy X-ray absorptiometry
目的：通过对初发的青壮年甲状腺功能亢进症（甲亢）患者的骨密度（BMD）的测定，研究甲亢患者骨代谢的特征。方法采用双能X线吸收法对我院369例初发未经治疗的青壮年甲亢患者组和148名健康对照组进行腰椎L2-4，股骨近端的BMD检测，同时测定甲状腺功能、AKP、PTH、CT、24 h尿钙、血钙等。结果比较甲亢组与健康对照组的FT3、FT4和TSH差异有统计学意义（P<0.01），甲亢组的血钙、PTH和CT与对照组比较无统计学差异（P>0.05）；甲亢骨量正常组24 h尿钙与对照组比较差异无统计学意义（P>0.05），而甲亢骨量异常组24 h尿钙与对照组比较有显著性差异（P<0.05）；甲亢患者BMD与血清FT3、FT4呈负相关，与TSH呈正相关。结论通过甲状腺功能、骨密度及骨代谢指标的研究分析，发现甲亢将导致青壮年骨量减少和骨质疏松，因此在治疗甲亢时，不应忽略对骨质疏松的预防。
目的：通過對初髮的青壯年甲狀腺功能亢進癥（甲亢）患者的骨密度（BMD）的測定，研究甲亢患者骨代謝的特徵。方法採用雙能X線吸收法對我院369例初髮未經治療的青壯年甲亢患者組和148名健康對照組進行腰椎L2-4，股骨近耑的BMD檢測，同時測定甲狀腺功能、AKP、PTH、CT、24 h尿鈣、血鈣等。結果比較甲亢組與健康對照組的FT3、FT4和TSH差異有統計學意義（P<0.01），甲亢組的血鈣、PTH和CT與對照組比較無統計學差異（P>0.05）；甲亢骨量正常組24 h尿鈣與對照組比較差異無統計學意義（P>0.05），而甲亢骨量異常組24 h尿鈣與對照組比較有顯著性差異（P<0.05）；甲亢患者BMD與血清FT3、FT4呈負相關，與TSH呈正相關。結論通過甲狀腺功能、骨密度及骨代謝指標的研究分析，髮現甲亢將導緻青壯年骨量減少和骨質疏鬆，因此在治療甲亢時，不應忽略對骨質疏鬆的預防。
목적：통과대초발적청장년갑상선공능항진증（갑항）환자적골밀도（BMD）적측정，연구갑항환자골대사적특정。방법채용쌍능X선흡수법대아원369례초발미경치료적청장년갑항환자조화148명건강대조조진행요추L2-4，고골근단적BMD검측，동시측정갑상선공능、AKP、PTH、CT、24 h뇨개、혈개등。결과비교갑항조여건강대조조적FT3、FT4화TSH차이유통계학의의（P<0.01），갑항조적혈개、PTH화CT여대조조비교무통계학차이（P>0.05）；갑항골량정상조24 h뇨개여대조조비교차이무통계학의의（P>0.05），이갑항골량이상조24 h뇨개여대조조비교유현저성차이（P<0.05）；갑항환자BMD여혈청FT3、FT4정부상관，여TSH정정상관。결론통과갑상선공능、골밀도급골대사지표적연구분석，발현갑항장도치청장년골량감소화골질소송，인차재치료갑항시，불응홀략대골질소송적예방。
Objective To study the characteristics of bone metabolism by detecting bone mineral density (BMD) of young patients with hyperthyroidism. Methods The BMD of lumbar L2-4 and proximal femur in 369 cases of untreated patients with hyperthyroidism and 148 healthy controls were detected by dual-energy X-ray absorptiometry. The thyroid function, AKP, PTH, CT, 24 h urinary calcium, serum calcium were also detected. Results Comparison of FT3, FT4 and TSH between hyperthyroidism group and control group, which had statistically significant difference (P<0.01). And the serum calcium, PTH and CT in hyperthyroidism group and control group had no statistical difference (P>0.05). There were no significant difference of 24 h urine calcium in hyperthyroidism bone mass normal group and control group (P>0.05). And 24 h urine calcium in hyperthyroidism abnormal bone mass group and the control group were significant difference (P<0.05). The BMD were negatively correlated with serum FT3, FT4 in hyperthyroidism patients, and positively correlated with TSH. Conclusion It was found that hyperthyroidism could cause bone loss and osteoporosis in young adults through the analysis of thyroid function, BMD and bone metabolism. So the prevention of osteoporosis should not be ignored in the treatment of hyperthyroidism..
