CAJ | 학술논문

目的：了解近3年南京地区儿童血培养中病原菌的分布及耐药趋势。方法对2009年1月至2011年12月南京市儿童医院送检的血培养标本检出菌的分布和药物敏感性试验结果进行回顾性分析。结果14232例血培养标本中分离出2489株病原菌，分离率为17．5％，其中革兰阳性菌2082株，占83．6％，革兰阴性菌344株，占13．8％，真菌63株，占2．6％。革兰阳性菌主要以凝固酶阴性葡萄球菌（CNS）为主，革兰阴性菌检出率较高的为大肠埃希菌。主要革兰阳性菌对万古霉素、环丙沙星、利福平敏感，对青霉素耐药严重。主要革兰阴性菌对亚胺培南、阿米卡星、头孢哌酮-舒巴坦敏感。结论南京地区儿童血培养病原菌主要以革兰阳性菌为主，血培养检出菌耐药情况严重，临床应根据病原菌种类和药物敏感性试验结果合理使用抗菌药物。
목적：료해근3년남경지구인동혈배양중병원균적분포급내약추세。방법대2009년1월지2011년12월남경시인동의원송검적혈배양표본검출균적분포화약물민감성시험결과진행회고성분석。결과14232례혈배양표본중분리출2489주병원균，분리솔위17．5％，기중혁란양성균2082주，점83．6％，혁란음성균344주，점13．8％，진균63주，점2．6％。혁란양성균주요이응고매음성포도구균（CNS）위주，혁란음성균검출솔교고적위대장애희균。주요혁란양성균대만고매소、배병사성、리복평민감，대청매소내약엄중。주요혁란음성균대아알배남、아미잡성、두포고동-서파탄민감。결론남경지구인동혈배양병원균주요이혁란양성균위주，혈배양검출균내약정황엄중，림상응근거병원균충류화약물민감성시험결과합리사용항균약물。
Objective To investigate the distribution and drug resistance of pathogenic bacteria from blood culture of children in Nanjing during recent 3 years.Methods The distribution and drug resistance of pathogenic bacteria from blood culture of children in Nanjing Children′s Hospital from January 2009 to December 201 1 were analyzed retrospectively.Results Totally 2 489 isolates of bacteria were collected from 1 4 232 blood culture samples.The isolation rate was 1 7.5%.A total of 2 082 isolates of Gram positive bacteria accounted for 83.6%.Gram negative bacteria and fungi accounted for 1 3.8% (344 isolates)and 2.6%(63 isolates),respectively.The main of Gram positive bacteria was coagulase negative Staphylococcus(CNS),and Escherichia coli was the most part of Gram negative bacteria.Gram positive bacteria were sensitive to vancomycin,ciprofloxacin and rifampicin and resistant to penicillin seriously.Gram negative bacteria were sensitive to imipenem,amikacin and cefoperazone-sulbactam.Conclusions Gram positive bacteria are the most frequently pathogenic bacteria from blood culture of children in Nanjing.Drug resistance is serious in these isolates.We should recognize the results of drug sensitivity tests and the indication of pathogenic bacteria to use antibiotics reasonably.