CAJ | 학술논문

目的探讨脑深部电刺激术(deep brain stimulation,DBS)治疗扭转痉挛(torsion dystonia,TD)的疗效.方法 3例TD患者,其中2例行双侧苍白球内侧部-脑深部电刺激术(GPi-DBS),1例行双侧丘脑底核-脑深部电刺激术(STN-DBS).3例患者术前及术后3、6、12个月分别采用Burke-Fahn-Marsden肌张力障碍运动评分量表(Burke-Fahn-Marsden Dystonia Rating Scale,BFMDRS)进行评分.结果所有患者开机后症状立即都有不同程度的改善,随访3、6、12个月,2例行GPi-DBS的患者改善率为61％～98％；1例行STN-DBS的患者改善率为40％～ 60％.所有患者未出现手术相关并发症及永久性不良反应.结论 DBS是一种安全、有效治疗TD的方法,但长期疗效尚待进一步随访.
목적 탐토뇌심부전자격술(deep brain stimulation,DBS)치료뉴전경련(torsion dystonia,TD)적료효.방법 3례TD환자,기중2례행쌍측창백구내측부-뇌심부전자격술(GPi-DBS),1례행쌍측구뇌저핵-뇌심부전자격술(STN-DBS).3례환자술전급술후3、6、12개월분별채용Burke-Fahn-Marsden기장력장애운동평분량표(Burke-Fahn-Marsden Dystonia Rating Scale,BFMDRS)진행평분.결과 소유환자개궤후증상립즉도유불동정도적개선,수방3、6、12개월,2례행GPi-DBS적환자개선솔위61％～98％；1례행STN-DBS적환자개선솔위40％～ 60％.소유환자미출현수술상관병발증급영구성불량반응.결론 DBS시일충안전、유효치료TD적방법,단장기료효상대진일보수방.
Objective To assess clinical efficacy of deep brain stimulation in the treatment of three cases of torsion dystonia (TD).Methods Two TD patients underwent bilateral globus pallidus internus deep brain stimulation (GPi-DBS).Another patient underwent bilateral subthalamic nucleus deep brain stimulation(STN-DBS).Preoperative and postoperative (3 months,6 months,12 months)Burke-Fahn-Marsden dystonia rating scale (BFMDRS) were performed on each patient.Results All patients experienced immediate improvement before starting stimulation.Three patients were followed-up over 12 months.The two patients with GPi-DBS showed improvement from 61％ to 98％.The patient with STN-DBS showed improvement from 40％ to 60％.All patients had no surgery-related complications and permanent side effects.Conclusions Stereotactic bilateral GPi-DBS or STN-DBS may be an effective and safe for the treatment of TD.However,the long-term effect should be followed up.