CAJ | 학술논문

背景：在过去20余年中，围绕着胆囊收缩素的临床应用以及在神经损伤中的作用进行了广泛的研究。目的：探讨胆囊收缩素在神经损伤后的作用及其可能的作用机制。方法：通过检索近年来关于胆囊收缩素的生物学特性及其在神经系统中的生物学作用相关文献，从动物实验的细胞、器官水平对这些相关研究成果作回顾性分析，总结胆囊收缩素在神经损伤后的作用及其可能的作用机制等方面的研究。结果与结论：胆囊收缩素及其受体在体内的广泛分布，其在生理及病理状态下的作用也复杂多样，但对胆囊收缩素的神经保护作用的研究还不充分，大部分实验还仅局限于对现象的观察，胆囊收缩素对神经保护的作用机制尚值得深入研究，为最终应用于临床奠定基础。
배경：재과거20여년중，위요착담낭수축소적림상응용이급재신경손상중적작용진행료엄범적연구。목적：탐토담낭수축소재신경손상후적작용급기가능적작용궤제。방법：통과검색근년래관우담낭수축소적생물학특성급기재신경계통중적생물학작용상관문헌，종동물실험적세포、기관수평대저사상관연구성과작회고성분석，총결담낭수축소재신경손상후적작용급기가능적작용궤제등방면적연구。결과여결론：담낭수축소급기수체재체내적엄범분포，기재생리급병리상태하적작용야복잡다양，단대담낭수축소적신경보호작용적연구환불충분，대부분실험환부국한우대현상적관찰，담낭수축소대신경보호적작용궤제상치득심입연구，위최종응용우림상전정기출。
BACKGROUND:In the past 20 years, cholecystokinin in clinical application and nerve repair has been extensively studied. OBJECTIVE:To explore the role of cholecystokinin in nerve repair and its possible mechanism of action. METHODS:Relevant research results were retrospectively analyzed at the celland organ levels through retrieving recent literatures concerning the biological characteristics of cholecystokinin and its biological role in the nervous system. Then, we summarized the effect of cholecystokinin after nerve injury and its possible RESULTS AND CONCLUSION:Cholecystokinin and its receptors are widely distributed in the body, and under physiological and pathological conditions, their roles were complex and diverse. However, studies addressing the neuroprotective effect of cholecystokinin are not sufficient, most of which are limited to phenomenon observation. Neuroprotective mechanism of cholecystokinin is stil worthy of further studies, which can provide the basis for the clinical application.