CAJ | 학술논문

背景：生长因子诱导细胞向纤维软骨分化是半月板组织工程研究热点。半月板的体外构建和体内重塑与生长因子的作用关系密切。目的：概述近年来生长因子半月板组织工程研究进展，并对其机制进行探讨。方法：应用计算机检索2008年1月至2013年3月维普数据库(http：//lib.cqvip.com)、中国知网数据库(www.cnki.net)及Pubmed数据库(http：//www.ncbi.nlm.nih.gov/pubmed)相关文章，以“半月板组织工程；软骨；生长因子”为中文检索词；以“meniscus tissue engineering, cartilage, growth factors”为英文检索词。纳入53篇关于半月板组织工程中生长因子研究的文章。结果与结论：软骨组织工程研究中生长因子的种类繁多，新的生长因子亦在不断的被发现。生长因子对软骨调节作用的研究，从以前的单一生长因子模式开始向多生长因子间相互作用研究模式转变；生长因子对软骨调节作用的分子机制也得到了广泛的研究。生长因子在组织工程中具有良好的运用前景，但还存在着许多尚待解决的问题，如在半月板愈合过程中，不同时间阶段、不同生长因子的表达与作用均不相同，因此如何适时、适量以及怎样发挥生长因子之间的相互作用来更好的模拟体内微环境，探究生长因子对软骨调节作用的分子机制以及发现新的生长因子等都将是半月板组织工程中的研究重点。
배경：생장인자유도세포향섬유연골분화시반월판조직공정연구열점。반월판적체외구건화체내중소여생장인자적작용관계밀절。목적：개술근년래생장인자반월판조직공정연구진전，병대기궤제진행탐토。방법：응용계산궤검색2008년1월지2013년3월유보수거고(http：//lib.cqvip.com)、중국지망수거고(www.cnki.net)급Pubmed수거고(http：//www.ncbi.nlm.nih.gov/pubmed)상관문장，이“반월판조직공정；연골；생장인자”위중문검색사；이“meniscus tissue engineering, cartilage, growth factors”위영문검색사。납입53편관우반월판조직공정중생장인자연구적문장。결과여결론：연골조직공정연구중생장인자적충류번다，신적생장인자역재불단적피발현。생장인자대연골조절작용적연구，종이전적단일생장인자모식개시향다생장인자간상호작용연구모식전변；생장인자대연골조절작용적분자궤제야득도료엄범적연구。생장인자재조직공정중구유량호적운용전경，단환존재착허다상대해결적문제，여재반월판유합과정중，불동시간계단、불동생장인자적표체여작용균불상동，인차여하괄시、괄량이급즘양발휘생장인자지간적상호작용래경호적모의체내미배경，탐구생장인자대연골조절작용적분자궤제이급발현신적생장인자등도장시반월판조직공정중적연구중점。
BACKGROUND:Differentiation of growth factor-induced cells into fibrocartilage is the hot topic in the research of meniscus tissue engineering. The in vitro construction and in vivo reconstruction of menisci are closely related with the effect of growth factors. OBJECTIVE:To review the current development of growth factors in meniscus tissue engineering, and to investigate the mechanism. METHODS:The VIP database (http://lib.cqvip.com), CNKI database (www.cnki.net) and PubMed database (http://www.ncbi.nlm.nih.gov/pubmed) were retrieved for the related articles from January 2008 to March 2013 with the key words of“meniscus tissue engineering, cartilage, growth factors”. A total of 53 articles on the research of growth factors in meniscus tissue engineering were included. RESULTS AND CONCLUSION:There were various growth factors in cartilage tissue engineering research, and the new growth factors have been found in the constant. The research on the regulation effect of growth factors on cartilage was changed from the research of single growth factor model to the research of the interactions between multiple growth factors;the molecular mechanisms of growth factors in regulating the cartilage have also been extensively studied. Growth factors have good application prospects in tissue engineering, but there are stil many problems to be solved, such as during the healing of menisci, the expressions and the effect of different growth factors are different in different time points. So how to play the interaction between growth factors timely and appropriately thus stimulating the in vivo microenvironment, investigating the molecular mechanisms of growth factors in regulating the cartilage, as wel as finding the new growth factors are the research focus in meniscus tissue engineering.