CAJ | 학술논문

中医药在慢性肝病、尤其对慢性炎症损伤、肝纤维化的治疗中具有一定的优势，但其药效成分和作用机制的研究仍面临巨大的挑战。介绍了近年来以虚拟筛选技术、各种组学技术以及网络药理学为主要内容的计算机药理学方法及其在中医药研究领域中的应用；结合研究实践对计算机药理学方法解析中药治疗慢性肝病的有效成分及作用机制的进展作了评述。认为综合运用计算机药理学的技术，结合传统的分子生物学、药理学方法，是解析治疗慢性肝病有效中药药效物质基础及作用机制的重要研究策略。
중의약재만성간병、우기대만성염증손상、간섬유화적치료중구유일정적우세，단기약효성분화작용궤제적연구잉면림거대적도전。개소료근년래이허의사선기술、각충조학기술이급망락약이학위주요내용적계산궤약이학방법급기재중의약연구영역중적응용；결합연구실천대계산궤약이학방법해석중약치료만성간병적유효성분급작용궤제적진전작료평술。인위종합운용계산궤약이학적기술，결합전통적분자생물학、약이학방법，시해석치료만성간병유효중약약효물질기출급작용궤제적중요연구책략。
Traditional Chinese medicine (TCM)has certain advantages in the treatment of chronic liver diseases,especially chronic inflam-matory injury and liver fibrosis.However,the studies on medicinal components and action mechanism of TCM prescriptions are confronted with a great challenge.The computational pharmacology methods used in recent years,mainly including virtual screening technique,omics technologies,and network pharmacology approaches,as well as their application in TCM research,are presented;given the previous re-search work,the progress in research on active ingredients and action mechanism of TCM prescriptions using computational pharmacology methods is reviewed.It is thought that computational pharmacology techniques combined with conventional molecular biological and pharma-cological methods are an important research strategy for the material basis and action mechanism of TCMprescriptions for treating chronic liv-er diseases.