CAJ | 학술논문

目的探讨原发性十二指肠肿瘤手术疗效和预后因素。方法对2001年5月至2012年7月41例行外科手术切除治疗并经术后病理证实的原发性十二指肠肿瘤患者的临床资料进行回顾性分析。采用单因素和多因素分析评估预后因素与术后生存期的关联性。结果主要的临床表现有上腹部不适27例、黄疸19例、消瘦12例、食欲缺乏4例；术后总体5年生存率为62.3％，行胰十二指肠切除术27例（65.9％）和行局部肿物切除术10例（24.4％），其中26例十二指肠恶性肿瘤患者行胰十二指肠切除术术后5年生存率为50.5％；行其他术式4例。在单因素分析中，肿瘤的性质（ P＝0.036），恶性肿瘤的大小（ P＝0.033）和分期（ P＝0.010）与预后有关。结论胰十二指肠切除术和局部切除术均是延长生存期的可行而有效治疗方法；肿瘤的性质，恶性肿瘤的大小和分期可影响患者预后。
목적탐토원발성십이지장종류수술료효화예후인소。방법대2001년5월지2012년7월41례행외과수술절제치료병경술후병리증실적원발성십이지장종류환자적림상자료진행회고성분석。채용단인소화다인소분석평고예후인소여술후생존기적관련성。결과주요적림상표현유상복부불괄27례、황달19례、소수12례、식욕결핍4례；술후총체5년생존솔위62.3％，행이십이지장절제술27례（65.9％）화행국부종물절제술10례（24.4％），기중26례십이지장악성종류환자행이십이지장절제술술후5년생존솔위50.5％；행기타술식4례。재단인소분석중，종류적성질（ P＝0.036），악성종류적대소（ P＝0.033）화분기（ P＝0.010）여예후유관。결론이십이지장절제술화국부절제술균시연장생존기적가행이유효치료방법；종류적성질，악성종류적대소화분기가영향환자예후。
Objective To investigate the treatment effect of surgery and the prognostic factors of primary duodenal tumor.Methods From May 2001 to July 2012,the medical records of 41 patients with primary duodenal tumor who underwent resection were retrospectively reviewed .Univariate and multivariate analyses were performed to evaluate the correlation of prognostic factors and survival time after resection .Results The main clinical symptoms were discomfort of upper abdomen ( 27 cases ) , jaundice ( 19 cases ) , athrepsy ( 12 cases ) and anorexia ( 4 cases ) . Overall survival after resection was 62.3%at 5 years in this study.27 cases(65.9%)in pancreatioduodenectomy and 10 cases(24.4%)in local resection,the 5 years survival rate of the 26 cases with duodenal malignancy underwent pancreaticoduodenectomy was 50.5%.4 cases in other operations .In the univariate , the nature of the tumor ( P =0.036),the size of cancer(P=0.033)and TNM stage(P=0.010),which were associated with the survival time. Conclusion Pancreatioduodenectomy and local resection were the effective and feasible treatments which could prolong the life span after resection .The nature of the tumor and the size of malignancy and TNM stage were of influence on the life span after resection .