CAJ | 학술논문

目的探讨MRI测量健康中国人嗅觉相关中枢结构梨状皮质及杏仁核周围皮质（ PCA）和眶额叶皮质（ OFC）体积可行性及其随年龄变化的规律。方法87例（男∶女＝44∶43）右利手健康志愿者纳入本研究，年龄20.0～69.9岁，每10岁为一组将其分为五个年龄组。应用Dr．View软件在冠状位T1WI上手工逐层测量并计算PCA和OFC体积。结果各年龄组之间PCA体积无明显差异， OFC体积随着年龄的增长呈逐渐缩小的趋势，但在40岁以前呈相对稳定的规律，自40岁以后开始逐渐缩小。相关分析显示，年龄与PCA体积之间无明显相关性，但与 OFC 体积之间呈负相关（左侧：r ＝-0.409， P ＜0.001；右侧：r ＝-0.369，P＜0.001），即随着年龄的增长，左右两侧OFC体积均逐渐缩小。结论本研究利用MRI测量提供了健康中国人PCA及OFC体积的正常值范围，并发现OFC体积随年龄增长而逐渐缩小的规律，为临床检测嗅觉功能异常和诊断相关疾病提供一种客观的评价方法。
목적탐토MRI측량건강중국인후각상관중추결구리상피질급행인핵주위피질（ PCA）화광액협피질（ OFC）체적가행성급기수년령변화적규률。방법87례（남∶녀＝44∶43）우리수건강지원자납입본연구，년령20.0～69.9세，매10세위일조장기분위오개년령조。응용Dr．View연건재관상위T1WI상수공축층측량병계산PCA화OFC체적。결과각년령조지간PCA체적무명현차이， OFC체적수착년령적증장정축점축소적추세，단재40세이전정상대은정적규률，자40세이후개시축점축소。상관분석현시，년령여PCA체적지간무명현상관성，단여 OFC 체적지간정부상관（좌측：r ＝-0.409， P ＜0.001；우측：r ＝-0.369，P＜0.001），즉수착년령적증장，좌우량측OFC체적균축점축소。결론본연구이용MRI측량제공료건강중국인PCA급OFC체적적정상치범위，병발현OFC체적수년령증장이축점축소적규률，위림상검측후각공능이상화진단상관질병제공일충객관적평개방법。
Objective To depict the changing rules of MRI volumes of piriform-cortical amygdala(PCA), orbitofrontal cortices ( OFC) ,and the relationships between volumes of PCA ,OFC and age in Chinese healthy adults , also the normal volumes of each age group .Methods One hundred and eleven healthy right-handed participants (54 males,57 females)from age 20 to 70 years were recruited to join this study.All the subjects accept MRI scan,and volumetric measurements of the PCA and OFC were performed using consecutive 1-mm thick coronal slices of MRIs with Dr.view software.Results Significant age differences were observed in the volume of OFC ,shown as becoming significantly reduced after 40 years old .Similar age-related volumetric changes were not found in the PCA . Additionally,Pearson partial correlation analyses revealed significant correlations between age and the volume of OFC ( left:r=-0.409 ,P<0.001;right:r=-0.369 ,P<0.001 ) .Conclusion Taking together ,the present data might be expected to contribute to establishing normative database for olfactory function and volumes of PCA and OFC .The volumes of bilateral OFC but not of the PCA were significantly declined with age .The present data provides the clinical objective evaluation method for testing the olfactory functions and might be useful in assessing the diseases which affect olfaction .