CAJ | 학술논문

目的评价白眉蛇毒血凝酶对接受腹腔镜胆囊切除的老年患者的止血作用及安全性.方法采用前瞻、随机、盲法、对照研究,满足方案入选标准并获得知情同意的≥65岁的老年患者共60例分为两组,研究组(30例):术前20 min静脉注射白眉蛇毒血凝酶(邦亭)2U,术后4h再次注射1U,对照组(30例):给予生理盐水；观察记录术中腹腔出血和术后24 h腹腔引流量；同时观察凝血功能变化和安全性. 结果 59例完成研究,淘汰1例.研究组术中出血量为(53.6±68.1)g,少于对照组的(88.1±79.7)g(t=2.08,P=0.038)；术后24 h两组腹腔引流量分别为(71.7±113.3)g和(89.0±104.7)g,两组比较差异无统计学意义(t=1.69.P=0.075)；凝血功能指标两组结果均相似；未出现血栓等并发症,住院时间研究组(5.2±1.4)d与对照组(5.3±1.7)d,两组比较差异无统计学意义(t=0.52 P=0.61);未出现与研究药物相关的不良事件. 结论腹腔镜胆囊切除的老年患者应用白眉蛇毒血凝酶有较好的止血作用和安全性.
목적 평개백미사독혈응매대접수복강경담낭절제적노년환자적지혈작용급안전성.방법 채용전첨、수궤、맹법、대조연구,만족방안입선표준병획득지정동의적≥65세적노년환자공60례분위량조,연구조(30례):술전20 min정맥주사백미사독혈응매(방정)2U,술후4h재차주사1U,대조조(30례):급여생리염수；관찰기록술중복강출혈화술후24 h복강인류량；동시관찰응혈공능변화화안전성. 결과 59례완성연구,도태1례.연구조술중출혈량위(53.6±68.1)g,소우대조조적(88.1±79.7)g(t=2.08,P=0.038)；술후24 h량조복강인류량분별위(71.7±113.3)g화(89.0±104.7)g,량조비교차이무통계학의의(t=1.69.P=0.075)；응혈공능지표량조결과균상사；미출현혈전등병발증,주원시간연구조(5.2±1.4)d여대조조(5.3±1.7)d,량조비교차이무통계학의의(t=0.52 P=0.61);미출현여연구약물상관적불량사건. 결론 복강경담낭절제적노년환자응용백미사독혈응매유교호적지혈작용화안전성.
Objective To evaluate the hemostatic effect of hemocoagulase agkistrodon in elderly patients undergoing laparoscopic cholecystectomy and to analyze its influence on coagulation function and its safety.Methods A prospective,randomized,double blind and controlled research was conducted in 60 patients aged over 65 years.Patients were divided into 2 groups:the study group and the control group (n =30 each group).Patients in the study group were injected with 2 U hemocoagulase agkistrodon intravenously 20 minutes before operation and with 1 U hemocoagulase agkistrodon 4 hours after operation.Patients in the control group were injected with physiological saline instead of hemocoagulase agkistrodon.The intraoperative intraperitoneal hemorrhage and intraperitoneal drainage at 24 hours after operation were recorded.The changes in bemagglutination and safety were observed.Results 59 cases were finished in this study and 1 case was eliminated.The volume of intraoperative hemorrhage was less in the study group than in the control group [(53.6±68.1) g vs.(88.1±79.7) g,t =2.08,P=0.038].There was no significant difference in the volume of intraperitoneal drainage at 24 hours after operation between the study group and the control group [(71.7±113.3) g vs.(89.0±104.7) g,t =1.69,P=0.075].The hemoagglutinationindexes were similar between two groups and no thrombosis occurred.There was no significant difference in the time of hospital stay between the study group and the control group [(5.2±1.4) days vs.(5.3±1.7) days,t=0.52,P=0.61].No adverse event was reported.Conclusions Hemocoagulase agkistrodon has relatively good hemostatic effects and safety for the elderly patients undergoing laparoscopic cholecystectomy.