国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2011年
16期
2030-2032
,共3页
陈波%陈巧珊%刘肖瑛%阮富旺
陳波%陳巧珊%劉肖瑛%阮富旺
진파%진교산%류초영%원부왕
心肌损害%肌酸激酶%肌酸激酶同工酶%肌钙蛋白Ⅰ%联合检验
心肌損害%肌痠激酶%肌痠激酶同工酶%肌鈣蛋白Ⅰ%聯閤檢驗
심기손해%기산격매%기산격매동공매%기개단백Ⅰ%연합검험
Myocardial injury%Creatine kinase(CK)%Creatine kinase isozyme-MB(CK-MB)%Troponin Ⅰ(cTnI)%Joint survey
目的 探讨婴幼儿患者血清、CK-MB及cTnI对心肌损害的诊断价值.方法 对196例和102例心电图和临床表现有、无心肌损害表现的婴幼儿患者和正常对照儿童进行血清CK、CK-MB及cTnI测定.结果 有心肌损害组三项指标分别为CK(236.2±127.2)U/L;CK-MB(32.2±12.7)U/L;cTnI(0.24±0.13)ng/ml,均明显高于无心肌损害表现组及正常对照组(P＜0.01),但特异性和敏感性却不尽相同,联合检验的敏感性及准确性达93.4%和80.5%,均有显著提高(P＜0.05).结论 血清CK、CK-MB及cTnI在对婴幼儿患者心肌损害反映中,CK、CK-MB特异性不高,同时要考虑到单纯CK、CK-MB活性增高可能是生理、标本和试剂等因素所致,不具有临床诊断价值;cTnI特异性最高,但在心肌轻度损害时敏感性不高;因此诊断婴幼儿患者心肌损害时应联合这三项并结合心电图和临床表现来综合确定诊断.
目的 探討嬰幼兒患者血清、CK-MB及cTnI對心肌損害的診斷價值.方法 對196例和102例心電圖和臨床錶現有、無心肌損害錶現的嬰幼兒患者和正常對照兒童進行血清CK、CK-MB及cTnI測定.結果 有心肌損害組三項指標分彆為CK(236.2±127.2)U/L;CK-MB(32.2±12.7)U/L;cTnI(0.24±0.13)ng/ml,均明顯高于無心肌損害錶現組及正常對照組(P＜0.01),但特異性和敏感性卻不儘相同,聯閤檢驗的敏感性及準確性達93.4%和80.5%,均有顯著提高(P＜0.05).結論 血清CK、CK-MB及cTnI在對嬰幼兒患者心肌損害反映中,CK、CK-MB特異性不高,同時要攷慮到單純CK、CK-MB活性增高可能是生理、標本和試劑等因素所緻,不具有臨床診斷價值;cTnI特異性最高,但在心肌輕度損害時敏感性不高;因此診斷嬰幼兒患者心肌損害時應聯閤這三項併結閤心電圖和臨床錶現來綜閤確定診斷.
목적 탐토영유인환자혈청、CK-MB급cTnI대심기손해적진단개치.방법 대196례화102례심전도화림상표현유、무심기손해표현적영유인환자화정상대조인동진행혈청CK、CK-MB급cTnI측정.결과 유심기손해조삼항지표분별위CK(236.2±127.2)U/L;CK-MB(32.2±12.7)U/L;cTnI(0.24±0.13)ng/ml,균명현고우무심기손해표현조급정상대조조(P＜0.01),단특이성화민감성각불진상동,연합검험적민감성급준학성체93.4%화80.5%,균유현저제고(P＜0.05).결론 혈청CK、CK-MB급cTnI재대영유인환자심기손해반영중,CK、CK-MB특이성불고,동시요고필도단순CK、CK-MB활성증고가능시생리、표본화시제등인소소치,불구유림상진단개치;cTnI특이성최고,단재심기경도손해시민감성불고;인차진단영유인환자심기손해시응연합저삼항병결합심전도화림상표현래종합학정진단.
Objective To explore the diagnostic value of serum CK, CK-MB, cTnI to myocardial injury in the infant patients. Methods Determination was made to serum CK, CK - MB and cTnI for 196 examples and 102patients with electrocardiogram and clinical expression with and without a myocardial impairment performance of no myocardial injury patients and normal children as control. Results Three indexes of the myocardial injury group were CK (236.2 ± 127.2) U/L; CK-MB (32.2 ± 12.7) U/L, cTnI (0.24 ± 0.13) ng/ml respectively, significantly higher than those in the group without myocardial impairment performance and control group(P ＜ 0.01), but the specificity and sensitivity were different, and the sensitivity and accuracy of the Joint inspection attained 93.4% and 80.5%, both data fields had significant improves (P ＜ 0.05). Conclusions The reaction of the serum CK, CK-MB and the cTnI for infant patients myocardial injury showed that CK, CK-MB specificity is not high, at the same time,we should consider the activity increasing of the pure CK, CK-MB may result from physiology, specimens and reagents, without clinical diagnostic value. The cTnI has the highest specificity, but in myocardial mild damage the sensitivity is not high, so the diagnosis to infant patients myocardial injury should combine with these three factors, as well as the electrocardiogram and clinical expression for comprehensive confirmation.
