国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
14期
2055-2056
,共2页
汕尾市%育龄人群%α地中海贫血基因%β地中海贫血基因%分布
汕尾市%育齡人群%α地中海貧血基因%β地中海貧血基因%分佈
산미시%육령인군%α지중해빈혈기인%β지중해빈혈기인%분포
Shanwei%Reproductive population%Alpha thalassaemia gene%Beta thalassaemia gene%Distribution
目的 了解汕尾市育龄人群中α、β地中海贫血基因型的分布情况.方法 采用整群抽样方法选择2013年1月1日至2013年12月31日各地区部分住院分娩和引产的孕产妇、配偶共计1200例作为研究对象,分别进行α-地中海贫血和β-地中海贫血调查.结果 在1200份血液标本中共计检测出6种α-地中海贫血基因型,共计62例,63个等位基因,α-地中海贫血基因携带率为5.25％(63/1200).其基因型构成比:-a3.7/aa 31个,占总数的49.21％;-aSEA/aa 18个,占总数的28.57％;-a4.2/aa 7个,占总数的11.11％;-aTHAI/aa 2个,占总数的3.17％;--SEA/--SEA 3个,占总数的4.76％;--aCSa/aa2个,占总数的3.17％.有13例患者检测出携带β-地中海贫血基因,β-地中海贫血基因携带率为1.08％.基因类型共有5种,其构成比:IVS-2-654(C→T)和-28(A→G)各23.08％,CD41/42(-TCTT)30.77％,CD17(A→T)15.38％,βECD26(C→A)7.69％.结论 汕尾市区α-地中海贫血基因携带率和β-地中海贫血基因携带率从整个省份来讲相对较低,但分析自身数据来看携带率还是较高,主要发生在遗传背景较复杂的地区,并主要以本地人群为主.
目的 瞭解汕尾市育齡人群中α、β地中海貧血基因型的分佈情況.方法 採用整群抽樣方法選擇2013年1月1日至2013年12月31日各地區部分住院分娩和引產的孕產婦、配偶共計1200例作為研究對象,分彆進行α-地中海貧血和β-地中海貧血調查.結果 在1200份血液標本中共計檢測齣6種α-地中海貧血基因型,共計62例,63箇等位基因,α-地中海貧血基因攜帶率為5.25％(63/1200).其基因型構成比:-a3.7/aa 31箇,佔總數的49.21％;-aSEA/aa 18箇,佔總數的28.57％;-a4.2/aa 7箇,佔總數的11.11％;-aTHAI/aa 2箇,佔總數的3.17％;--SEA/--SEA 3箇,佔總數的4.76％;--aCSa/aa2箇,佔總數的3.17％.有13例患者檢測齣攜帶β-地中海貧血基因,β-地中海貧血基因攜帶率為1.08％.基因類型共有5種,其構成比:IVS-2-654(C→T)和-28(A→G)各23.08％,CD41/42(-TCTT)30.77％,CD17(A→T)15.38％,βECD26(C→A)7.69％.結論 汕尾市區α-地中海貧血基因攜帶率和β-地中海貧血基因攜帶率從整箇省份來講相對較低,但分析自身數據來看攜帶率還是較高,主要髮生在遺傳揹景較複雜的地區,併主要以本地人群為主.
목적 료해산미시육령인군중α、β지중해빈혈기인형적분포정황.방법 채용정군추양방법선택2013년1월1일지2013년12월31일각지구부분주원분면화인산적잉산부、배우공계1200례작위연구대상,분별진행α-지중해빈혈화β-지중해빈혈조사.결과 재1200빈혈액표본중공계검측출6충α-지중해빈혈기인형,공계62례,63개등위기인,α-지중해빈혈기인휴대솔위5.25％(63/1200).기기인형구성비:-a3.7/aa 31개,점총수적49.21％;-aSEA/aa 18개,점총수적28.57％;-a4.2/aa 7개,점총수적11.11％;-aTHAI/aa 2개,점총수적3.17％;--SEA/--SEA 3개,점총수적4.76％;--aCSa/aa2개,점총수적3.17％.유13례환자검측출휴대β-지중해빈혈기인,β-지중해빈혈기인휴대솔위1.08％.기인류형공유5충,기구성비:IVS-2-654(C→T)화-28(A→G)각23.08％,CD41/42(-TCTT)30.77％,CD17(A→T)15.38％,βECD26(C→A)7.69％.결론 산미시구α-지중해빈혈기인휴대솔화β-지중해빈혈기인휴대솔종정개성빈래강상대교저,단분석자신수거래간휴대솔환시교고,주요발생재유전배경교복잡적지구,병주요이본지인군위주.
objective To understand the distribution of alpha and beta thalassaemia genotypes in childbearing age people in Shanwei.Methods Pregnant woment and their spouses 1200 cases were chosen from the hospitals of each area from January 1st to December 1st 2013 as study objects using cluster sampling method.Alpha beta thalassaemia were investigated respectively.Results Among the 1200 blood samples,6 kinds of alpha thalassaemia genotypes were detected,with a total of 62 cases,63 alleles.The alpha thalassaemia gene carrying rate was 5.25％ (63/1200).The genotype composition:31-a3.7/aa,49.21％ of the total; 18-aSEA/aa,28.57％ of the total; 7-a4.2/aa,11.11％ of the total; 2-aTHAI/aa,3.17％ of the total; 3--SEA/--SEA,4.76％ of the total; 2-aCSa/aa,3.17％ of the total.13 cases were detected with beta thalassemia gene,with a beta thalassemia gene carrying rate of 1.08％.There were five genetic types of beta thalassemia gene including IVS-2-654 (C → T) and-28 (A → G) (both accounted for 23.08％),CD41/42 (-TCTT) (30.77％),CD17 (A → T) (15.38％),and beta ECD26 (C → A) (7.69％).Conclusions The alpha thalassaemia gene carrying rate and beta thalassaemia carrying rate of Shanwei are relatively lower among the whole province.However,but the analysis of the data showed that the carrying rate was high,thalassaemia genes were carried mainly by people,most of which are natives,in regions with complex genetic background.
