CAJ | 학술논문

目的：：探讨髓过氧化物酶特异性抗中性粒细胞胞浆抗体(MPO-ANCA)在系统性硬化症(SSc)中的临床意义。方法：采用间接免疫荧光(IIF)法及免疫印迹法,检测98例SSc患者血清中ANCA水平,并从中分析MPO-ANCA与SSc相关的临床特点的关系。结果：MPO-ANCA在SSc中的阳性率是12.2%(12/98),MPO-ANCA阳性组SSc患者出现肾脏累及、合并甲状腺功能减低及抗Scl-70抗体阳性的频率均显著高于MPO-ANCA阴性组SSc患者。结论：MPO-ANCA在SSc中的阳性率为12.2%,并与其特定的临床表现相关,推测MPO-ANCA可能在SSc的发病过程起一定的作用。
목적：：탐토수과양화물매특이성항중성립세포포장항체(MPO-ANCA)재계통성경화증(SSc)중적림상의의。방법：채용간접면역형광(IIF)법급면역인적법,검측98례SSc환자혈청중ANCA수평,병종중분석MPO-ANCA여SSc상관적림상특점적관계。결과：MPO-ANCA재SSc중적양성솔시12.2%(12/98),MPO-ANCA양성조SSc환자출현신장루급、합병갑상선공능감저급항Scl-70항체양성적빈솔균현저고우MPO-ANCA음성조SSc환자。결론：MPO-ANCA재SSc중적양성솔위12.2%,병여기특정적림상표현상관,추측MPO-ANCA가능재SSc적발병과정기일정적작용。
Objective:To test the prevalence of MPO-ANCA and to elucidate the clinical significance of serum MPO-ANCA in patients with systemic sclerosis (SSc).Methods:MPO-ANCA was detected in sera obtained from 98 patients with SSc by Immunofluorescence and Western blot, and its relationship to clinical and laboratory findings was analyzed.Results:MPO-ANCA was detected in sera of 12 (12.2%) patients with SSc.The prevalence of renal involved,coexistence of hypothyroidism and anti-scl-70 antibody were all significantly higher in MPO-ANCA-positive patients than in MPO-ANCA-negative patients(P<0.05).Conclusion:The prevalence of MPO-ANCA was 12.2%in SSc and its presence correlated with particular clinical manifestations. The presence of MPO-ANCA in SSc patients indicate that MPO-ANCA may play a pathogenetic role in SSc.