CAJ | 학술논문

S100 A7是一种小分子钙结合蛋白，广泛参与到上皮细胞的分化、皮肤化学防御体系的构建、氧化应激和炎症反应的发生等生命过程，其分泌可由物理、化学和生物等多方面因素诱导。 S100 A7具有多种结合配体，并通过特定的信号通路与活性氧类密切相关。作为皮肤的一种重要抗菌肽，S100A7能帮助人体表皮抵御常见致病微生物的侵袭。 S100A7也在多种皮肤病中表达上调，是反映皮肤细胞分化程度和炎症状态的关键指标。另外，脑组织神经元中S100 A7的高表达可阻止阿尔兹海默症患者脑中淀粉样蛋白的沉积。 S100 A7在某些肿瘤组织中也呈现高表达，与癌症的发生和恶化密切相关。文中介绍S100 A7的生物学特性及功能，总结S100 A7在多种疾病中的表达特征和作用机制，为寻找S100 A7相关疾病的分子标记物和作用靶点提供新思路。
S100 A7시일충소분자개결합단백，엄범삼여도상피세포적분화、피부화학방어체계적구건、양화응격화염증반응적발생등생명과정，기분비가유물리、화학화생물등다방면인소유도。 S100 A7구유다충결합배체，병통과특정적신호통로여활성양류밀절상관。작위피부적일충중요항균태，S100A7능방조인체표피저어상견치병미생물적침습。 S100A7야재다충피부병중표체상조，시반영피부세포분화정도화염증상태적관건지표。령외，뇌조직신경원중S100 A7적고표체가조지아이자해묵증환자뇌중정분양단백적침적。 S100 A7재모사종류조직중야정현고표체，여암증적발생화악화밀절상관。문중개소S100 A7적생물학특성급공능，총결S100 A7재다충질병중적표체특정화작용궤제，위심조S100 A7상관질병적분자표기물화작용파점제공신사로。
S100 A7 is a small calcium-binding protein that has an important role to play in the differentiation of human kerati -nocytes.It also helps build the chemical defense system of the skin and responds to oxidative stress and inflammation .The expression of S100 A7 can be induced by physical , chemical and biological stimulations .S100 A7 has many ligands and is related to the reactive oxygen species (ROS) via specific signaling pathways.As an important antimicrobial peptide, S100A7 helps the skin fight against main pathogens .S100 A7 is also a key indicator for the state of inflammation and cell differentiation;and its up-regulation has been cor-roborated in various skin diseases .In the brain of patients with Alzheimer′s disease, the up-regulation of S100A7 in primary cortico-hippocampal neurons can inhibit the generation of β-amyloid peptides .Moreover , S100 A7 is also up-regulated in different types of cancer and closely related to tumor malignancy and progression .In this review, we introduce biological properties of S 100A7 and high-light its expression characteristic in related diseases .This should have implication for the discovery of potential biomarkers and targets for the treatment of S100A7-related diseases.