中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
5期
842-843
,共2页
手术%化疗%口腔鳞状细胞癌%标志物
手術%化療%口腔鱗狀細胞癌%標誌物
수술%화료%구강린상세포암%표지물
Surgery%Chemotherapy%Oral squamous cell carcinoma%Markers
目的：：探讨手术联合化疗在口腔鳞状细胞癌治疗中的疗效及血清肿瘤标志物的变化。方法：60例鳞状细胞癌患者随机分为联合组与对照组,每组各30例,对照组给予静脉滴注尿嘧啶和多烯紫杉醇,观察组给予静脉滴注尿嘧啶和多烯紫杉醇联合手术治疗,比较两组的临床治疗效果及血清标志物的改变情况。结果：(1)联合组鳞状细胞癌患者的总有效率90.0%(27/30),对照组患者总有效率70.0%(21/30),组间比较差异有统计学意义(P<0.05)；(2)两组鳞状细胞癌患者在治疗过程中均出现不同程度的细胞减少、恶心、呕吐以及脱发等不良反应,联合组总发生率53.3%(16/30),对照组总发生率60.0%(18/30),组间比较差异无统计学意义(P>0.05)；(3)联合组的HGF(265.28±45.56)ng/L、VEGF(192.34±37.72)ng/L、uPA(2.45±0.81)ng/L,对照组的HGF(377.90±62.37)ng/L、VEGF(425.18±115.36)ng/L、uPA(4.75±1.28)ng/L,联合组均明显低于对照组(P<0.05)。结论：手术联合多烯紫杉醇、尿嘧啶对口腔鳞状细胞癌具有较好的临床效果,改善了患者的临床症状,提高口腔鳞状细胞癌患者的生活质量。
目的：：探討手術聯閤化療在口腔鱗狀細胞癌治療中的療效及血清腫瘤標誌物的變化。方法：60例鱗狀細胞癌患者隨機分為聯閤組與對照組,每組各30例,對照組給予靜脈滴註尿嘧啶和多烯紫杉醇,觀察組給予靜脈滴註尿嘧啶和多烯紫杉醇聯閤手術治療,比較兩組的臨床治療效果及血清標誌物的改變情況。結果：(1)聯閤組鱗狀細胞癌患者的總有效率90.0%(27/30),對照組患者總有效率70.0%(21/30),組間比較差異有統計學意義(P<0.05)；(2)兩組鱗狀細胞癌患者在治療過程中均齣現不同程度的細胞減少、噁心、嘔吐以及脫髮等不良反應,聯閤組總髮生率53.3%(16/30),對照組總髮生率60.0%(18/30),組間比較差異無統計學意義(P>0.05)；(3)聯閤組的HGF(265.28±45.56)ng/L、VEGF(192.34±37.72)ng/L、uPA(2.45±0.81)ng/L,對照組的HGF(377.90±62.37)ng/L、VEGF(425.18±115.36)ng/L、uPA(4.75±1.28)ng/L,聯閤組均明顯低于對照組(P<0.05)。結論：手術聯閤多烯紫杉醇、尿嘧啶對口腔鱗狀細胞癌具有較好的臨床效果,改善瞭患者的臨床癥狀,提高口腔鱗狀細胞癌患者的生活質量。
목적：：탐토수술연합화료재구강린상세포암치료중적료효급혈청종류표지물적변화。방법：60례린상세포암환자수궤분위연합조여대조조,매조각30례,대조조급여정맥적주뇨밀정화다희자삼순,관찰조급여정맥적주뇨밀정화다희자삼순연합수술치료,비교량조적림상치료효과급혈청표지물적개변정황。결과：(1)연합조린상세포암환자적총유효솔90.0%(27/30),대조조환자총유효솔70.0%(21/30),조간비교차이유통계학의의(P<0.05)；(2)량조린상세포암환자재치료과정중균출현불동정도적세포감소、악심、구토이급탈발등불량반응,연합조총발생솔53.3%(16/30),대조조총발생솔60.0%(18/30),조간비교차이무통계학의의(P>0.05)；(3)연합조적HGF(265.28±45.56)ng/L、VEGF(192.34±37.72)ng/L、uPA(2.45±0.81)ng/L,대조조적HGF(377.90±62.37)ng/L、VEGF(425.18±115.36)ng/L、uPA(4.75±1.28)ng/L,연합조균명현저우대조조(P<0.05)。결론：수술연합다희자삼순、뇨밀정대구강린상세포암구유교호적림상효과,개선료환자적림상증상,제고구강린상세포암환자적생활질량。
Objective:To study the efficacy of surgery combined with chemotherapy treatment in the oral squamous cell carcinoma , and to explore the change of serum levels of tumor markers in these patients.Methods:A total of 60 cases of squamous cell carcinoma patients were divided into the combined group and the control group The control group was given intravenously uracil and docetaxel, while the observation group was given intravenously uracil and docetaxel combined surgery. The clinical outcomes of the two groups were observed.Results:(1) The patients of combined group showed total efficiency (90.0%) which was significantly higher than that of control group (70.0%) (х2=4.268,P=0.017<0.05);(2) During the treatment, there were different degrees of cells decreased, nausea, vomiting and hair loss and other adverse reactions in all patients, The total efficiency in combined group was 52.0%,which was significantly lower than that in control group (60.0%).There was no difference between these two group(P>0.05);(3) The level of HGF, VEGF and uPA levels in combination group were all significantly lower than that in control group.Conclusion:For oral squamous cell carcinoma patients,the Surgery combined with docetaxel, uracil showed value clinical effect,.It can improve the patient's life quality.
