CAJ | 학술논문

目的：探讨血清降钙素原(PCT)水平对手足口病合并细菌感染患儿早期鉴别诊断的意义。方法回顾性分析2012年1-7月某院住院的234例手足口病患儿病历资料,按照出院诊断结果分为单纯病毒感染组(178例)和合并细菌感染组(56例),同时选取20名健康儿童资料作为对照组,进行血清PCT、C反应蛋白(CRP)及外周血白细胞(WBC)计数的比较。结果各组血清PCT、CRP及外周血 WBC水平的比较,差异均有统计学意义(F值分别为381.94、24.18和26.46,均P<0.05)。各组血清PCT、CRP及外周血WBC水平的阳性检出率比较,差异均有统计学意义(χ2值分别为178.25、38.98和71.21,均P<0.05),其中合并细菌感染组的血清 PCT、CRP 及外周血 WBC水平阳性检出率[分别为92.86%(52/56)、85.71%(48/56)和87.50%(49/56)]明显高于单纯病毒感染组[分别为3.93%(7/178)、62.36%(111/178)和30.90%(55/178)]及健康对照组[分别为5.00%(1/20)、10.00%(2/20)和5.00%(1/20)]。PCT、CRP及外周血WBC的敏感度分别为92.86%、85.71%和87.50%,特异度分别为95.00%、90.00%和95.00%。结论 PCT水平对于鉴别手足口病合并细菌感染具有重要价值,其准确率、敏感性优于CRP及 WBC水平,能指导临床用药。
목적：탐토혈청강개소원(PCT)수평대수족구병합병세균감염환인조기감별진단적의의。방법회고성분석2012년1-7월모원주원적234례수족구병환인병력자료,안조출원진단결과분위단순병독감염조(178례)화합병세균감염조(56례),동시선취20명건강인동자료작위대조조,진행혈청PCT、C반응단백(CRP)급외주혈백세포(WBC)계수적비교。결과각조혈청PCT、CRP급외주혈 WBC수평적비교,차이균유통계학의의(F치분별위381.94、24.18화26.46,균P<0.05)。각조혈청PCT、CRP급외주혈WBC수평적양성검출솔비교,차이균유통계학의의(χ2치분별위178.25、38.98화71.21,균P<0.05),기중합병세균감염조적혈청 PCT、CRP 급외주혈 WBC수평양성검출솔[분별위92.86%(52/56)、85.71%(48/56)화87.50%(49/56)]명현고우단순병독감염조[분별위3.93%(7/178)、62.36%(111/178)화30.90%(55/178)]급건강대조조[분별위5.00%(1/20)、10.00%(2/20)화5.00%(1/20)]。PCT、CRP급외주혈WBC적민감도분별위92.86%、85.71%화87.50%,특이도분별위95.00%、90.00%화95.00%。결론 PCT수평대우감별수족구병합병세균감염구유중요개치,기준학솔、민감성우우CRP급 WBC수평,능지도림상용약。
Objective To evaluate the role of procalcitonin (PCT)in the early diagnosis for hand,foot and mouth disease (HFMD)with bacterial infection.Methods Clinical data of 234 HFMD children who were hospitalized be-tween January and July 2012 were analyzed retrospectively,according to discharge diagnosis,data were divided into simple viral infection group (n=178)and viral associated with bacterial infection group (n=56),and data of 20 healthy children were selected as the control group.Serum PCT,C-reactive protein (CRP)and peripheral white blood cell (WBC)count were compared.Results There was significant difference in the level of PCT,CRP and WBC among three groups (F=381.94,24.18,and 26.46,respectively,all P<0.05).The positive rate of PCT,CRP and WBC among three groups was significantly different(χ2=178.25,38.98,and 71.21,all P<0.05),PCT,CRP and WBC in bacterial infection group(92.86%[52/56],85.71%[48/56],and 87.50%[49/56]respectively)were significantly higher than those of simple viral infection group (3.93%[7/178],62.36%[111/178],and 30.90%[55/178]respectively)and healthy control group (5.00%[1/20],10.00%[2/20],and 5.00%[1/20]respectively).The sensitivity rate of PCT,CRP and WBC was 92.86%,85.71%,and 87.50% respectively,specificity rate was 95.00%,90.00%,and 95.00% respectively.Conclusion The level of PCT has important value for the early diagno-sis of HFMD with bacterial infection,and its accuracy rate and sensitivity are better than CRP and WBC levels.