CAJ | 학술논문

目的：探讨围手术期预防使用抗菌药物对甲状腺手术切口感染的影响。方法在抗菌药物使用整顿前后,医院感染管理专职人员对某三级甲等医院甲状腺手术患者抗菌药物使用和手术切口愈合情况及医院感染情况进行调查并比较。结果2011年4-8月(整顿前)甲状腺手术抗菌药物使用率为99.53%(211/212),2012年4-8月(整顿后)甲状腺手术抗菌药物使用率为10.89%(22/202),整顿前后抗菌药物使用率比较,差异有统计学意义(χ2=334.23,P<0.001)。2011年4-8月发生医院感染8例,医院感染率为3.77%(8/212),其中切口感染3例(1.42%)；2012年4-8月发生医院感染6例,医院感染率为2.97%(6/202),其中切口感染2例(0.99%)。两组病例医院感染率及切口感染率比较,差异均无统计学意义(P>0.05)。结论该院的甲状腺手术围手术期用药经规范后,减少了围手术期抗菌药物的使用,但并未导致甲状腺手术术后切口感染和医院感染率的增加。
목적：탐토위수술기예방사용항균약물대갑상선수술절구감염적영향。방법재항균약물사용정돈전후,의원감염관리전직인원대모삼급갑등의원갑상선수술환자항균약물사용화수술절구유합정황급의원감염정황진행조사병비교。결과2011년4-8월(정돈전)갑상선수술항균약물사용솔위99.53%(211/212),2012년4-8월(정돈후)갑상선수술항균약물사용솔위10.89%(22/202),정돈전후항균약물사용솔비교,차이유통계학의의(χ2=334.23,P<0.001)。2011년4-8월발생의원감염8례,의원감염솔위3.77%(8/212),기중절구감염3례(1.42%)；2012년4-8월발생의원감염6례,의원감염솔위2.97%(6/202),기중절구감염2례(0.99%)。량조병례의원감염솔급절구감염솔비교,차이균무통계학의의(P>0.05)。결론해원적갑상선수술위수술기용약경규범후,감소료위수술기항균약물적사용,단병미도치갑상선수술술후절구감염화의원감염솔적증가。
Objective To evaluate the influence of perioperative antimicrobial prophylaxis in surgical site infection (SSI)following thyroid surgery.Methods Application of antimicrobial agents,healing status of surgical wound, and occurrence of healthcare-associated infection (HAI)in thyroid surgery patients before and after performing anti-microbial stewardship program were surveyed and compared.Results Antimicrobial use prevalence was 99.53%(211/212)in 2011 (from April to August,before stewardship intervention)and 10.89% (22/202)in 2012 (from April to August,after stewardship intervention),difference was statistically different(χ2=334.23,P<0.001 ). HAI rate was 3.77% (8/212)in 2011 and 2.97%(6/202)in 2012,and SSI rate was 1.42% (3/212)and 0.99%(2/202)respectively.There was no statistical difference in HAI and SSI rate between two groups(P>0.05).Con-clusion Rational perioperative antimicrobial prophylaxis enhanced significantly after antimicrobial stewardship pro-gram was performed,the reducing of perioperative antimicrobial use does not result in the increase of SSI and HAI rate.