CAJ | 학술논문

目的：探讨 T - cadherin 在胃癌组织中表达及其与 VEGF、MVD 之间的关系。方法：采用免疫组化 SP 法对80例胃癌组织及癌旁正常胃组织的 T - cadherin、血管内皮生长因子（ Vascular endothelial growth factor，VEGF）和 CD34的表达情况进行检测。结果：T - cadherin 主要在胃癌细胞膜上表达，阳性率为45.0%（36/80），而癌旁正常胃组织中 T - cadherin 阳性率为62.5%（50/80），两者比较差异有统计学意义（P＝0.026）。VEGF 在癌旁正常细胞阳性率为28.75%，在胃癌中表达阳性率为71.25%，差异有统计学意义（P＝0.000）。CD34阳性细胞着色部位主要是血管内皮细胞的胞膜和胞浆，胃癌中标记的微血管明显多于正常组织（54.96±7.28/ ePF vs 27.50±6.10/ ePF，P ﹤0.001）。T - cadherin 和 VEGF 蛋白表达呈负相关（ P＝0.001）；T - cadherin 阳性组的 MVD 值明显低于阴性低表达组（P ﹤0.001）. T - cadherin 、VEGF、CD343种蛋白在胃癌中的阳性表达与患者性别和年龄、肿瘤大小均无关（P ﹥0.05），但与组织分化程度、淋巴结转移及 PTNM 分期显著相关（P ﹤0.05）。结论：T - cadherin 的异常表达可以作为临床评价胃癌诊断、指导治疗及判断预后的辅助指标之一。
목적：탐토 T - cadherin 재위암조직중표체급기여 VEGF、MVD 지간적관계。방법：채용면역조화 SP 법대80례위암조직급암방정상위조직적 T - cadherin、혈관내피생장인자（ Vascular endothelial growth factor，VEGF）화 CD34적표체정황진행검측。결과：T - cadherin 주요재위암세포막상표체，양성솔위45.0%（36/80），이암방정상위조직중 T - cadherin 양성솔위62.5%（50/80），량자비교차이유통계학의의（P＝0.026）。VEGF 재암방정상세포양성솔위28.75%，재위암중표체양성솔위71.25%，차이유통계학의의（P＝0.000）。CD34양성세포착색부위주요시혈관내피세포적포막화포장，위암중표기적미혈관명현다우정상조직（54.96±7.28/ ePF vs 27.50±6.10/ ePF，P ﹤0.001）。T - cadherin 화 VEGF 단백표체정부상관（ P＝0.001）；T - cadherin 양성조적 MVD 치명현저우음성저표체조（P ﹤0.001）. T - cadherin 、VEGF、CD343충단백재위암중적양성표체여환자성별화년령、종류대소균무관（P ﹥0.05），단여조직분화정도、림파결전이급 PTNM 분기현저상관（P ﹤0.05）。결론：T - cadherin 적이상표체가이작위림상평개위암진단、지도치료급판단예후적보조지표지일。
Objective:To discuss T - cadherin exPression in gastric cancer and the relationshiP between VEGF, MVD. Methods:Using immunohistochemical SP method to test the exPression of T - cadherin,vascular endothelial growth factor(VEGF)and CD34 in 80 cases of gastric cancer tissue and normal gastric tissue adjacent to carcinoma. Results:T - cadherin exPressied in the gastric cancer cell membrane,Positive rate was 45. 0%(36 / 80),while in normal gastric tissues adjacent to carcinoma T - cadherin Positive rate was 62. 5%(50 / 80,P = 0. 026). VEGF in normal cells adjacent to carcinoma Positive rate was 28. 75% ,the exPression Positive rate was 71. 25% in cancer of the stomach(P = 0. 000). CD34 Positive cells mark of caPillaries in gastric cancer significantly more than the normal tissue(54. 96 ± 7. 28 / ePF vs 27. 50 ± 6. 10 / ePF,P ﹤ 0. 001). T - cadherin was negatively correlated with VEGF Protein exPression(P ﹤ 0. 001). The MVD value of T - cadherin Positive grouP was obviously lower than negative low exPression grouP(P ﹤ 0. 001). The T - cadherin,VEGF and CD34 in gastric cancer Patients were not correlatad gender,age,size,( P ﹥ 0 . 05 ),but with tissue differentiation degree and lymPh node metastasis and PTNM stage (P ﹤ 0. 05). Conclusion:T - cadherin abnormal exPression can be used for gastric cancer diagnosis,treatment and Prognosis evaluation.