CAJ | 학술논문

目的：观察他莫西芬片联合乳癖消片对乳腺增生病大鼠乳腺组织的影响。方法：将50只大鼠随机分为正常组、模型组、他莫昔芬片组、乳癖消片组和他莫昔芬片联合乳癖消片组（联合用药组）。给药30 d后，进行乳腺组织形态学观察与乳腺组织病理学检查。结果：与他莫昔芬片组、乳癖消片组比较，联合用药组大鼠的乳头直径、乳腺体积均明显缩小，小叶腺泡数减少，腺泡直径和导管直径均降低（P<0.01）。结论：联合用药治疗乳腺增生病大鼠的疗效优于单用他莫西芬片或单用乳癖消片治疗的疗效。
목적：관찰타막서분편연합유벽소편대유선증생병대서유선조직적영향。방법：장50지대서수궤분위정상조、모형조、타막석분편조、유벽소편조화타막석분편연합유벽소편조（연합용약조）。급약30 d후，진행유선조직형태학관찰여유선조직병이학검사。결과：여타막석분편조、유벽소편조비교，연합용약조대서적유두직경、유선체적균명현축소，소협선포수감소，선포직경화도관직경균강저（P<0.01）。결론：연합용약치료유선증생병대서적료효우우단용타막서분편혹단용유벽소편치료적료효。
Objective:To observe the effect of tamoxifen tablets combined with Rupixiao tablets on mammary gland of rats with mastoplasia. Methods:50 rats were randomly divided into normal group,model group,tamoxifen tablets group,Rupixi-ao tablets group and tamoxifen tablets combined with Rupixiao tablets group (drug combination group). 30 days after ad-ministration,histopathology examination and histomorphology observation of mammary gland were done. Results:Compared with tamoxifen tablets group and Rupixiao tablets group,mammillary diameter and volume of mammary gland were signifi-cantly deflated,the number of gland alveolus of folial was decreased,the diameter of gland alveolus and conduit were de-creased in drug combination group(P<0.01). Conclusion:Effect of drug combination group is better than that of tamoxifen tablets group and Rupixiao tablets group.