CAJ | 학술논문

目的：探讨脑梗死急性期同型半胱氨酸、超敏C-反应蛋白、纤维蛋白原及低密度脂蛋白（LDL）与疾病的严重程度及复发的关系。方法入选发病3天内入院的急性脑梗死患者267例，检测急性期同型半胱氨酸、超敏C-反应蛋白、纤维蛋白原等指标。应用临床神经功能缺损程度量表进行评分并分组，并进行6个月至1年随防以记录脑梗死复发情况。采用单因素方差分析、单相关分析及t检验进行统计分析。结果脑梗死不同严重程度组间同型半胱氨酸、超敏C-反应蛋白、纤维蛋白原及LDL的差异有统计学意义(P<0.05)；急性期临床神经功能缺损程度与同型半胱氨酸、超敏C-反应蛋白、纤维蛋白原显著正相关(r=0.278，P<0.001；r=0.386，P<0.001；r=0.316， P<0.001)；随访期脑梗死复发组与非复发组比较显示超敏反应蛋白、纤维蛋白原差异有统计学意义(P<0.05)。结论同型半胱氨酸、超敏C-反应蛋白、纤维蛋白原水平可反映脑梗死病情严重程度，超敏C-反应蛋白、纤维蛋白原与脑梗死复发关系密切。
목적：탐토뇌경사급성기동형반광안산、초민C-반응단백、섬유단백원급저밀도지단백（LDL）여질병적엄중정도급복발적관계。방법입선발병3천내입원적급성뇌경사환자267례，검측급성기동형반광안산、초민C-반응단백、섬유단백원등지표。응용림상신경공능결손정도량표진행평분병분조，병진행6개월지1년수방이기록뇌경사복발정황。채용단인소방차분석、단상관분석급t검험진행통계분석。결과뇌경사불동엄중정도조간동형반광안산、초민C-반응단백、섬유단백원급LDL적차이유통계학의의(P<0.05)；급성기림상신경공능결손정도여동형반광안산、초민C-반응단백、섬유단백원현저정상관(r=0.278，P<0.001；r=0.386，P<0.001；r=0.316， P<0.001)；수방기뇌경사복발조여비복발조비교현시초민반응단백、섬유단백원차이유통계학의의(P<0.05)。결론동형반광안산、초민C-반응단백、섬유단백원수평가반영뇌경사병정엄중정도，초민C-반응단백、섬유단백원여뇌경사복발관계밀절。
Objectives To investigate the correlations of homocysteine, high-sensitivity C-reactive, fibrinogen levels with severity and recurrence of the cerebral infarction. Methods Two hundred sixty-seven patients with acute cerebral infarction admitted to hospital within 3 days were enrolled, and their levels of homocysteine, high-sensitivity C-reactive and fibrinogen were examined at the acute period. Patients were devided into mild, moderate and severe groups according to the clinical nerve function detect scale and were followed up from 6 monthes and 1 year to record recurrence of cerebral infarction. Single factor analysis of variance, correlation analysis and t test were used for statistical analysis. Results The significant differences were noted on the levels of homocysteine, high-sensitivity C-reactive, fibrinogen and light desity lipoprotein (LDL) during the different severity groups of cerebral infarction (P<0.05). The clinical nerve function detect scale scores were positively correlated with homocysteine, high-sensitivity C-reactive, and fibrinogen levels (r=0.278,P<0.001;r=0.386,P<0.001;r=0.316,P<0.001). There was significant differences on the levels of high-sensitivity C-reactive and fibrinogen between the recurrent group and non-recurrent group P<0.05). Conclusions The levels of homocysteine, hgh-sensitivity C-reactive and fibrinogen could reflect the severity of cerebral infarction, and hgh-sensitivity C-creative and fibrinogen are closely related to the recurrence of cerebral infarction.