中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
4期
585-588
,共4页
袁铭%向阳%夏林霜%翟莉%杨颃%陈鹏
袁銘%嚮暘%夏林霜%翟莉%楊頏%陳鵬
원명%향양%하림상%적리%양항%진붕
痔疮胶囊%大黄素%大黄酚%薄层色谱法%高效液相色谱法
痔瘡膠囊%大黃素%大黃酚%薄層色譜法%高效液相色譜法
치창효낭%대황소%대황분%박층색보법%고효액상색보법
Zhichuang capsules%Emodin%Chrysophanol%TLC%HPLC
目的：建立痔疮胶囊的质量标准。方法：采用TLC法对处方中的大黄、功劳木、白芷、冰片进行定性鉴别；采用HPLC法对痔疮胶囊大黄中的大黄素、大黄酚进行含量测定。结果：定性鉴别易于判别,专属性强；含量测定中大黄素进样量在25.8~516.0 ng的范围内线性关系良好(r =0.9999),平均回收率为97.31%(RSD =0.69%,n =6),大黄酚进样量在51.1~1022.0 ng的范围内线性关系良好(r=1.0000),平均回收率为97.63%(RSD=0.72%,n=6)。结论：所建立的方法能准确可靠地进行定性、定量检测,重复性好,可作为痔疮胶囊的质量控制标准。
目的：建立痔瘡膠囊的質量標準。方法：採用TLC法對處方中的大黃、功勞木、白芷、冰片進行定性鑒彆；採用HPLC法對痔瘡膠囊大黃中的大黃素、大黃酚進行含量測定。結果：定性鑒彆易于判彆,專屬性彊；含量測定中大黃素進樣量在25.8~516.0 ng的範圍內線性關繫良好(r =0.9999),平均迴收率為97.31%(RSD =0.69%,n =6),大黃酚進樣量在51.1~1022.0 ng的範圍內線性關繫良好(r=1.0000),平均迴收率為97.63%(RSD=0.72%,n=6)。結論：所建立的方法能準確可靠地進行定性、定量檢測,重複性好,可作為痔瘡膠囊的質量控製標準。
목적：건립치창효낭적질량표준。방법：채용TLC법대처방중적대황、공로목、백지、빙편진행정성감별；채용HPLC법대치창효낭대황중적대황소、대황분진행함량측정。결과：정성감별역우판별,전속성강；함량측정중대황소진양량재25.8~516.0 ng적범위내선성관계량호(r =0.9999),평균회수솔위97.31%(RSD =0.69%,n =6),대황분진양량재51.1~1022.0 ng적범위내선성관계량호(r=1.0000),평균회수솔위97.63%(RSD=0.72%,n=6)。결론：소건립적방법능준학가고지진행정성、정량검측,중복성호,가작위치창효낭적질량공제표준。
Objective: To establish the quality standards for Zhichuang capsules. Methods: Rhubarb, Mahonia, Angelica and Borneol in the formula were identified by TLC, the content of emodin and chrysophanol from Rhubarb in Zhichuang capsules were deter-mined by HPLC. Results: The qualitative identification was easy to operate with good specificity. The linearity was good ( r =0. 999 9) within the range of 25.8-516.0ng and the average recovery was 97.31%(RSD=0.69%,n=6)for emodin, the linearity was good (r=1.000 0) within the range of 51.1-1 022.0ng and the average recovery was 97.63%(RSD=0.72%,n=6)for Chry-sophanol. Conclusion:The method is reliable and accurate, which can be applied as a quality control method of Zhichuang capsules.
