CAJ | 학술논문

目的：通过功能磁共振（functional magnetic resonance imaging ，fMRI）技术，探讨精神分裂症患者静息状态下默认网络与突显网络的功能连接特点。方法采用3.0T功能磁共振技术检测27例未用药的急性期精神分裂症患者与27名年龄、性别相匹配的健康对照静息状态下脑功能连接情况。使用SPM8、DPARSFA软件结合独立成分分析（independent component analysis，ICA）方法对影像学数据进行分析。结果与对照组相比，患者组默认网络中右侧额下被盖区、右侧楔前叶功能连接降低（P<0.05未校正），右侧扣带回中部、左侧额中回功能连接增高（P<0.05未校正）；突显网络中左侧额下回、右侧额下回、左侧前扣带回、左侧中央后回功能连接降低（P<0.05未校正），左侧颞上回功能连接增高（P<0.05未校正）。左侧颞上回的功能连接异常与阳性与阴性症状量表中阳性症状（P）评分成正相关（r=0.568，P=0.002），右侧楔前叶的功能连接异常与妄想（P1）评分呈负相关（r=-0.458，P=0.016）。结论本研究中未用药的急性期精神分裂症患者存在静息态默认网络、突显网络的功能连接异常，部分脑区的功能连接异常与精神症状相关。
목적：통과공능자공진（functional magnetic resonance imaging ，fMRI）기술，탐토정신분렬증환자정식상태하묵인망락여돌현망락적공능련접특점。방법채용3.0T공능자공진기술검측27례미용약적급성기정신분렬증환자여27명년령、성별상필배적건강대조정식상태하뇌공능련접정황。사용SPM8、DPARSFA연건결합독립성분분석（independent component analysis，ICA）방법대영상학수거진행분석。결과여대조조상비，환자조묵인망락중우측액하피개구、우측설전협공능련접강저（P<0.05미교정），우측구대회중부、좌측액중회공능련접증고（P<0.05미교정）；돌현망락중좌측액하회、우측액하회、좌측전구대회、좌측중앙후회공능련접강저（P<0.05미교정），좌측섭상회공능련접증고（P<0.05미교정）。좌측섭상회적공능련접이상여양성여음성증상량표중양성증상（P）평분성정상관（r=0.568，P=0.002），우측설전협적공능련접이상여망상（P1）평분정부상관（r=-0.458，P=0.016）。결론본연구중미용약적급성기정신분렬증환자존재정식태묵인망락、돌현망락적공능련접이상，부분뇌구적공능련접이상여정신증상상관。
Objective To explore the feature of functional connectivity of default mode network (DMN) and salience network (SN) in unmedicated schizophrenia patients during a resting state by functional magnetic resonance imaging (fM-RI). Methods The SPM8 and DPARSFA softwares combined with independent component analysis (ICA) were used to in-vestigate functional connectivity (FC) of the DMN and SN in 27 unmedicated patients with schizophrenia and 27 age-and gender-matched healthy controls. Results Concerning the DMN, patients with schizophrenia showed decreased FC in right inferior frontal gyrus , right precuneus(unadjusted P<0.05)and increased FC in right middle cingulate gyrus, left middle frontal gyrus(unadjusted P<0.05). With regard to the SN, patients showed reduced connectivity in left inferior frontal gyrus, right inferior frontal gyrus, left anterior cingulate, left postcentral gyrus(unadjusted P<0.05)and increased connectivity in left superior temporal gyrus(unadjusted P<0.05). Correlation analyses showed that the increased FC of left superior temporal gyrus significantly correlated with PANSS-positive symptoms(r=0.568,P=0.002)and decreased FC of right precuneus significantly negatively correlated with delusion symptom(r=-0.458,P=0.016). Conclusion This study provides evidence for resting state functional abnormalities of DMN and SN in unmedicated schizophrenia patients. These aberrant function connectivities in some brain regions of the two networks could be a source of abnormal introspectively-oriented mental actives.