CAJ | 학술논문

目的：观察苯巴比妥对农村地区惊厥性癫痫患者的疗效及不良反应，为贵州省农村地区癫痫患者的治疗提供可行方案。方法由经过培训的当地医师对农村地区惊厥性癫痫患者进行筛查，并由神经科专家进行确诊，采用苯巴比妥进行单药治疗，根据病情进行药物剂量调整，由当地医师进行定期随访管理和病情评估。根据癫痫发作减少的百分率评估疗效。结果本研究纳入509例患者，其中249例完成1年的治疗过程，癫痫发作频率至少减少50%，半数患者在服药第1个月就取得较好疗效，药物耐受性良好，总显效有效率达71.29%；女性疗效高于男性（χ2=6.34，P=0.011），依从性好的疗效高于依从性不好的（χ2=3.9，P=0.048）。结论本研究结果表明，苯巴比妥治疗方案适合农村惊厥性癫痫患者，经过初级培训的当地医师可以完成苯巴比妥治疗癫痫，多数惊厥性癫痫患者可以获得显著疗效，不良反应轻微。
목적：관찰분파비타대농촌지구량궐성전간환자적료효급불량반응，위귀주성농촌지구전간환자적치료제공가행방안。방법유경과배훈적당지의사대농촌지구량궐성전간환자진행사사，병유신경과전가진행학진，채용분파비타진행단약치료，근거병정진행약물제량조정，유당지의사진행정기수방관리화병정평고。근거전간발작감소적백분솔평고료효。결과본연구납입509례환자，기중249례완성1년적치료과정，전간발작빈솔지소감소50%，반수환자재복약제1개월취취득교호료효，약물내수성량호，총현효유효솔체71.29%；녀성료효고우남성（χ2=6.34，P=0.011），의종성호적료효고우의종성불호적（χ2=3.9，P=0.048）。결론본연구결과표명，분파비타치료방안괄합농촌량궐성전간환자，경과초급배훈적당지의사가이완성분파비타치료전간，다수량궐성전간환자가이획득현저료효，불량반응경미。
Objective To investigate the efficacy of Phenobarbital in the treatment of convulsive epilepsy in the rural areas of Guizhou Province and,explore a feasible regimen for the treatment of patients with epilepsy in rural areas. Meth-ods Patients with convulsive epilepsy were first screened by local general physicians with basic training in epilepsy and was then confirmed by local neurologists. The patients were given phenobarbital monotherapy and followed up by those lo-cal general physicians. Efficacy was evaluated by assessing the percentage reduction in seizure frequency from baseline and the retention of patients on treatment. Results Five hundred and nine patients were included in this study. Two hun-dred forty nine patients completed 12 months' treatment and their seizure frequency was decreased by at least 50%. Pheno-barbital demonstrated good effectiveness in half of the 249 patients at the first month and the total effective rate of pheno-barbital was 71.29%. Medication was well tolerated and reported adverse events were mild. Phenobarbital was more effec- tive in female patients (χ2=6.34,P=0.011) and patients with good compliance(χ2=3.9,P=0.048).Conclusions This phe-nobarbital treatment regimen may be suitable for the treatment of convulsive forms of epilepsy in rural areas of Guizhou. Phenobarbital can significantly reduce seizure frequency without serious adverse events, indicating that general physicians with basic training in epilepsy are able to provide epilepsy patients with appropriate phenobarbital treatment in rural area.