CAJ | 학술논문

[目的]探讨慢性心力衰竭（CHF）患者红细胞分布宽度（RDW）、N末端脑钠肽前体（NT-proBNP）及高敏C反应蛋白（hsCRP）与心功能分级及治疗前后的关系。[方法]测定97例CHF患者不同心功能分级的RDW、NT-proBNP和hsCRP水平，并与62名健康对照组比较；测定CHF患者入院时、治疗开始后48 h及出院时三者水平，进行治疗前后对比。[结果]患者RDW、NT-proBNP和hsCRP在不同心功能分级组和对照组之间差异均有统计学意义，且心功能越差，其浓度越高（均 P ＜0．01）；治疗48 h及患者出院时，三项指标均随治疗时间延长显著下降（均 P ＜0．01）。[结论]CHF患者心功能越差，RDW、NT-proBNP和hsCRP越高，三者可作为患者心衰严重程度和预后判断的预测指标。
[목적]탐토만성심력쇠갈（CHF）환자홍세포분포관도（RDW）、N말단뇌납태전체（NT-proBNP）급고민C반응단백（hsCRP）여심공능분급급치료전후적관계。[방법]측정97례CHF환자불동심공능분급적RDW、NT-proBNP화hsCRP수평，병여62명건강대조조비교；측정CHF환자입원시、치료개시후48 h급출원시삼자수평，진행치료전후대비。[결과]환자RDW、NT-proBNP화hsCRP재불동심공능분급조화대조조지간차이균유통계학의의，차심공능월차，기농도월고（균 P ＜0．01）；치료48 h급환자출원시，삼항지표균수치료시간연장현저하강（균 P ＜0．01）。[결론]CHF환자심공능월차，RDW、NT-proBNP화hsCRP월고，삼자가작위환자심쇠엄중정도화예후판단적예측지표。
[Objective] To explore the relationship of red blood cell distribution (RDW) ,N-terminal pro-brain natriuretic peptide(NT-proBNP) and high sensitivity C reactive protein (hsCRP) in chronic heart failure(CHF) with the classification of cardiac function and the treatment .[Methods] RDW ,NT-proBNP and hsCRP in 97 CHF patients with different cardiac function grading were determined and compared with 62 healthy controls .RDW , NT-proBNP and hsCRP on admission to hospital ,48h after treatment and at hospital discharge were determined and were compared between before and after treatment .[Results] There was significant difference in RDW ,NT-proBNP and hsCRP between CHF groups with different cardiac function grading and control group .The worse the cardiac function was ,the higher the concentrations were .Three indicators decreased with the prolongation of treatment duration at 48h after treatment and at hospital discharge (all P < 0 .01) .[Conclusion] The worse the cardiac function ,the higher the serum levels of RDW ,NT-proBNP and hsCRP .The 3 indicators can be used as the predictive markers for assessing the severity and prognosis of CHF patients .