CAJ | 학술논문

[目的]观察化脓性脑膜炎患儿脑脊液中肿瘤坏死因子-α（T N F-α）的变化，并探讨其与并发症的关系。[方法]30例化脓性脑膜炎患儿，根据是否出现并发症将其分为有并发症组（病例1组）9人（ n ＝9）及无并发症组（病例2组）21人（ n ＝21），对照组为10例无中枢神经系统疾病腰麻手术患儿，测定其脑脊液中TNF-α值并加以比较。[结果]化脓性脑膜炎患儿脑脊液中 TNF-α较对照组病例显著升高，差别有统计学意义（P ＜0．05）。且出现并发症组较之未出现并发症组也有明显升高，两者差别有统计学意义（P ＜0．05）。[结论]化脓性脑膜炎出现并发症的患儿脑脊液中TNF-α明显升高，其可以作为判断化脓性脑膜炎预后的重要标志物。
[목적]관찰화농성뇌막염환인뇌척액중종류배사인자-α（T N F-α）적변화，병탐토기여병발증적관계。[방법]30례화농성뇌막염환인，근거시부출현병발증장기분위유병발증조（병례1조）9인（ n ＝9）급무병발증조（병례2조）21인（ n ＝21），대조조위10례무중추신경계통질병요마수술환인，측정기뇌척액중TNF-α치병가이비교。[결과]화농성뇌막염환인뇌척액중 TNF-α교대조조병례현저승고，차별유통계학의의（P ＜0．05）。차출현병발증조교지미출현병발증조야유명현승고，량자차별유통계학의의（P ＜0．05）。[결론]화농성뇌막염출현병발증적환인뇌척액중TNF-α명현승고，기가이작위판단화농성뇌막염예후적중요표지물。
[Objective]To observe the change of tumor necrosis factor-alpha(TNF-α) in cerebrospinal fluid (CSF) of children with purulent meningitis ,and to explore its correlation with the complications .[Methods]According to whether or not complications ,30 patients with purulent meningitis were divided into the group with complications(case group 1 ,n=9) and the group without complications(case group 2 ,n=21) .Other 10 patients without central nervous system disease undergoing the surgery under lumbar anesthesia were selected as the control group .TNF-αin CSF was measured and compared .[Results]Compared with the control group , TNF-αin CSF of pediatric patients with purulent meningitis was increased markedly ,and there was significant difference( P < 0 .05) .Compared with the group without complications ,TNF-α in CSF of the group with complications was also increased ,and there was significant difference( P <0 .05) .[Conclusion]TNF-αin CSF of pediatric patients with purulent meningitis is increased obviously ,and may be used as an important marker of the prognosis of purulent meningitis .