CAJ | 학술논문

[目的]评估血清基质金属蛋白酶-1（MMP-1）、基质金属蛋白酶-9（MMP-9）、组织金属蛋白抑制因子-1（TIMP-1）和白介素-6（IL-6）水平和冠状动脉粥样硬化性心脏病（CAD）严重性之间的关系。[方法]连续性冠状动脉造影的患者100例，据病情分为5组：稳定型心绞痛（SAP）20例，不稳定型心绞痛（USAP）19例，非ST段抬高心肌梗死（NSTEMI）10例，急性ST段抬高心肌梗死（STEMI）21例和对照组（冠状动脉造影正常）30例。ELISA法检测患者 MMP-1、MMP-9、TIMP-1、IL-6的血清浓度，计算冠状动脉造影Gensini评分。[结果]USAP组、SAP组与对照组，STEMI组与NSTEMI组比较MMP-1水平较高；STEMI组MMP-9水平明显高于USAP组和对照组；5组间TIMP-1水平没有差异（ P＞0．05）。糖尿病患者MMP-1的水平升高，吸烟者体内MMP-9水平更高。MMP-1、MMP-9、IL-6水平与左前降支（LAD）狭窄和Gensini评分存在相关性。[结论]血清MMP-1，MMP-9和IL-6水平与CAD疾病严重性相关。
[목적]평고혈청기질금속단백매-1（MMP-1）、기질금속단백매-9（MMP-9）、조직금속단백억제인자-1（TIMP-1）화백개소-6（IL-6）수평화관상동맥죽양경화성심장병（CAD）엄중성지간적관계。[방법]련속성관상동맥조영적환자100례，거병정분위5조：은정형심교통（SAP）20례，불은정형심교통（USAP）19례，비ST단태고심기경사（NSTEMI）10례，급성ST단태고심기경사（STEMI）21례화대조조（관상동맥조영정상）30례。ELISA법검측환자 MMP-1、MMP-9、TIMP-1、IL-6적혈청농도，계산관상동맥조영Gensini평분。[결과]USAP조、SAP조여대조조，STEMI조여NSTEMI조비교MMP-1수평교고；STEMI조MMP-9수평명현고우USAP조화대조조；5조간TIMP-1수평몰유차이（ P＞0．05）。당뇨병환자MMP-1적수평승고，흡연자체내MMP-9수평경고。MMP-1、MMP-9、IL-6수평여좌전강지（LAD）협착화Gensini평분존재상관성。[결론]혈청MMP-1，MMP-9화IL-6수평여CAD질병엄중성상관。
[Objective] To evaluate the correlation between serum levels of MMP-1 ,MMP-9 ,TIMP-1 ,IL-6 and the severity of atherosclerotic coronary artery disease(CAD) .[Methods] According to the degree of the dis-ease ,100 consecutive patients undergoing coronary angiography were divided into 5 groups including stable angina pectoris group(SAP group ,n=20) ,unstable angina pectoris group(USAP group ,n=19) ,non-ST elevation my-ocardial infarction group(NSTEMI group ,n=10) ,acute ST elevation myocardial infarction group (STEMI group , n=21) and control group(normal coronary angiography group ,n=30) .Serum levels of MMP-1 ,MMP-9 ,TIMP-1 and IL-6 were detected with ELISA method .Meanwhile coronary angiographic Gensini score was calculated .[Results] Compared with USAP group ,SAP group and control group ,MMP-1 levels in STEMI group and NSTEMI group were higher .MMP-9 levels in STEMI group were obviously higher than those in USAP group and control group .There was no significant difference in TIMP-1 among 5 groups .MMP-1 levels in diabetic patients increased ,while MMP-9 levels in smokers were even higher .The levels of MMP-1 ,MMP-9 and IL-6 were corre-lated with left anterior descending artery (LAD) stenosis and angiographic Gensini score .[Conclusion]Serum lev-els of MMP-1 ,MMP-9 and IL-6 are correlated with the severity of CAD .