医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2013年
12期
2366-2367,2368
,共3页
糖尿病肾病/药物疗法%卡托普利/投药和剂量
糖尿病腎病/藥物療法%卡託普利/投藥和劑量
당뇨병신병/약물요법%잡탁보리/투약화제량
Diabetic Nephropathies/DT%Captopril/AD
[目的]探讨罗格列酮联合卡托普利治疗早期糖尿病肾病(DN )的疗效。[方法]入住本院的DN患者80例,随机分为观察组和对照组各40例,在给予降糖药二甲双胍控制血糖后,分别给予罗格列酮联合卡托普利治疗及单纯卡托普利治疗,观察两组治疗后空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-D)、低密度脂蛋白胆固醇(LDL-C)、尿微量蛋白(mAlb)、收缩压(SBP)、舒张压(DBP)变化。[结果]两组患者治疗后 mAlb、FPG、TC、LDL-C、SBP、DBP均较治疗前显著下降( P <0.05);观察组mA1b、FPG下降较对照组更为显著( P <0.05)。对照组和观察组在治疗中分别出现1例和2例双下肢踝部轻度水肿。[结论]罗格列酮联合卡托普利治疗早期DN疗效较好,且使用安全。
[目的]探討囉格列酮聯閤卡託普利治療早期糖尿病腎病(DN )的療效。[方法]入住本院的DN患者80例,隨機分為觀察組和對照組各40例,在給予降糖藥二甲雙胍控製血糖後,分彆給予囉格列酮聯閤卡託普利治療及單純卡託普利治療,觀察兩組治療後空腹血糖(FPG)、總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-D)、低密度脂蛋白膽固醇(LDL-C)、尿微量蛋白(mAlb)、收縮壓(SBP)、舒張壓(DBP)變化。[結果]兩組患者治療後 mAlb、FPG、TC、LDL-C、SBP、DBP均較治療前顯著下降( P <0.05);觀察組mA1b、FPG下降較對照組更為顯著( P <0.05)。對照組和觀察組在治療中分彆齣現1例和2例雙下肢踝部輕度水腫。[結論]囉格列酮聯閤卡託普利治療早期DN療效較好,且使用安全。
[목적]탐토라격렬동연합잡탁보리치료조기당뇨병신병(DN )적료효。[방법]입주본원적DN환자80례,수궤분위관찰조화대조조각40례,재급여강당약이갑쌍고공제혈당후,분별급여라격렬동연합잡탁보리치료급단순잡탁보리치료,관찰량조치료후공복혈당(FPG)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-D)、저밀도지단백담고순(LDL-C)、뇨미량단백(mAlb)、수축압(SBP)、서장압(DBP)변화。[결과]량조환자치료후 mAlb、FPG、TC、LDL-C、SBP、DBP균교치료전현저하강( P <0.05);관찰조mA1b、FPG하강교대조조경위현저( P <0.05)。대조조화관찰조재치료중분별출현1례화2례쌍하지과부경도수종。[결론]라격렬동연합잡탁보리치료조기DN료효교호,차사용안전。
[Objective]To explore the efficacy of rosiglitazone combined with captopril for the treatment of early diabetic nephropathy(DN) .[Methods]A total of 80 DN patients were randomly divided into observation group and control group with 40 patients in each group .After given metformin to control blood sugar ,two groups received only captopril or combined with rosiglitazone ,respectively .Fasting blood glucose(FPG) ,total cholesterol(TC) ,triglycerides(TCT) ,high-density lipoprotein cholesterol(HDL-C) ,low-density lipoprotein cholesterol(LDL-C) ,urine protein(mAlb) ,systolic blood pressure(SBP) and diastolic blood pressure(DBP) after treatment were observed .[Results] Compared with before treatment ,mA1b ,FPG ,TC ,LDL-C ,SBP and DBP in two group after treatment were markedly decreased ( P <0 .05) .The mA1b and FPG in observa-tion group were decreased more significantly than those in control group ( P <0 .05) .Mild hydrops of ankles in both lower extremities was found in 1 patient of control group and 1 patient of observation group .[Conclu-sion]Rosiglitazone combined with captopril for the treatment of early DN has good efficacy and safety .