CAJ | 학술논문

[目的]探讨血清脂蛋白脂肪酶（L PL ）水平与帕金森病（PD ）患者认知损伤程度的相关性。[方法]采用简易精神状态评价量表（MMSE）与蒙特利尔认知评估（MoCA）评价 PD患者认知能力，分为无认知障碍、轻度认知障碍与重度认知障碍，检测不同PD患者血清LPL水平和血脂代谢产物水平，分析LPL水平与认知损伤程度的相关性，并与90名健康体检者相关检测指标水平对照。[结果]无认知障碍的PD患者血清L PL水平与健康体检者比较无显著性差异（ P＞0．05），有认知障碍的PD患者血清L PL水平较健康对照显著性下降（ P＜0．05）；轻度认知障碍与重度认知障碍患者LPL水平比较无显著性差异（ P ＞0．05）。不同组间血脂代谢产物水平无显著性差异（ P ＞0．05）。[结论]血清L PL水平的降低可能与 PD患者的认知能力下降有关。
[목적]탐토혈청지단백지방매（L PL ）수평여파금삼병（PD ）환자인지손상정도적상관성。[방법]채용간역정신상태평개량표（MMSE）여몽특리이인지평고（MoCA）평개 PD환자인지능력，분위무인지장애、경도인지장애여중도인지장애，검측불동PD환자혈청LPL수평화혈지대사산물수평，분석LPL수평여인지손상정도적상관성，병여90명건강체검자상관검측지표수평대조。[결과]무인지장애적PD환자혈청L PL수평여건강체검자비교무현저성차이（ P＞0．05），유인지장애적PD환자혈청L PL수평교건강대조현저성하강（ P＜0．05）；경도인지장애여중도인지장애환자LPL수평비교무현저성차이（ P ＞0．05）。불동조간혈지대사산물수평무현저성차이（ P ＞0．05）。[결론]혈청L PL수평적강저가능여 PD환자적인지능력하강유관。
[Objective]To explore the correlation between serum lipoprotein lipase (LPL ) and cognitive impairment ex-tent of patients with Parkinson's disease(PD) .[Methods]MMSE and MoCA were used to evaluate the cognitive function of PD patients .The cognitive function was divided into no cognitive impairment ,mild cognitive impairment and severe cognitive impairment .Serum LPL and blood lipid metabolites of PD patients were detected .The correlation between LPL and cognitive impairment extent was analyzed .Meanwhile ,90 healthy volunteers were collected and taken as the controls .[Results]There was no significant difference in serum LPL between PD patients without cognitive impairment and healthy controls ( P >0 .05) .Compared with healthy controls ,serum LDL of PD patients with cognitive impairment was markedly decreased ( P<0 .05) .There was no significant difference in LPL between mild cognitive impairment patients and severe cognitive impair-ment patients( P>0 .05) .There was no significant difference in blood lipid metabolites among different groups .[Conclusion]The decreasing of serum LPL may be correlated with the decreasing of cognitive ability of PD patients .