CAJ | 학술논문

目的：探讨消旋卡多曲治疗小儿轮状病毒性肠炎的临床效果。方法选取本院小儿轮状病毒性肠炎患者96例，随机分为两组，病毒唑治疗患儿48例为对照组，消旋卡多曲治疗患儿48例为观察组，比较两组患儿的病症改善情况、临床疗效、不良反应情况。结果观察组患儿的止吐时间（2.1±0.7）d、止泻时间（2.5±0.9）d、退热时间（1.8±0.6）d、住院时间（4.6±1.3）d均明显小于对照组（2.6±1.0）d、（3.2±1.1）d、（2.3±0.8）d、（6.7±1.5）d，观察组总有效率（97.9%）明显高于对照组（85.4%），观察组不良反应发生率（4.2%）明显低于对照组（16.7%），差异显著（P＜0.05）。结论消旋卡多曲是治疗小儿轮状病毒性肠炎的有效药物，可明显改善患儿的临床病症，缩短治疗时间，临床疗效好且安全性高。
목적：탐토소선잡다곡치료소인륜상병독성장염적림상효과。방법선취본원소인륜상병독성장염환자96례，수궤분위량조，병독서치료환인48례위대조조，소선잡다곡치료환인48례위관찰조，비교량조환인적병증개선정황、림상료효、불량반응정황。결과관찰조환인적지토시간（2.1±0.7）d、지사시간（2.5±0.9）d、퇴열시간（1.8±0.6）d、주원시간（4.6±1.3）d균명현소우대조조（2.6±1.0）d、（3.2±1.1）d、（2.3±0.8）d、（6.7±1.5）d，관찰조총유효솔（97.9%）명현고우대조조（85.4%），관찰조불량반응발생솔（4.2%）명현저우대조조（16.7%），차이현저（P＜0.05）。결론소선잡다곡시치료소인륜상병독성장염적유효약물，가명현개선환인적림상병증，축단치료시간，림상료효호차안전성고。
Objective To investigate the clinical effect of racecadotril in treatment for rotavirus enteritis in children. Methods 96 patients with rotavirus enteritis were selected in hospital, who were randomly divided into two groups. 48 patients treated ribavirin as control group. 48 patients treated racecadotril as observation group. Symptoms improvement situation, clinical efficacy, adverse reactions were compared between two groups. Results Antiemetic time(2.1±0.7)d; antidiarrheal time(2.5±0.9)d; cooling time(1.8±0.6) d; hospitalization time(4.6±1.3)d in observation group were significantly less than control group(2.6±1.0)d, (3.2±1.1)d, (2.3±0.8)d, (6.7±1.5)d. Total effective rate in observation group(97.9%) was significantly higher than control group(85.4%).Incidence of adverse reactions in observation group(4.2%) was significantly lower than control group(16.7%). Differences were statistically significant(P<0.05). Conclusion Racecadotril is an effective drug in treatment for rotavirus enteritis in children, which can significantly improve clinical symptoms and shorten treatment time.That has good clinical efficacy and high safety.