CAJ | 학술논문

目的：观察他汀类降脂药对急慢性脑血管病的远期疗效及卒中再发风险的影响。方法选取2009年5月～2010年5月我院就诊的急慢性脑血管病患者215例，随机分为研究组107例及对照组108例，观察IMT及动脉粥样硬化斑块面积的变化及血脂改变、心脑血管不良事件发生情况。结果治疗组患者治疗后与对照组TG、TC、LDL-C及HDL-C比较，差异有统计学意义（P＜0.05）。两组患者12、18、24个月时两组IMT值比较，差异有统计学意义（P＜0.05）；对所有患者随访2年，研究组致死性脑卒中、非致死性脑卒中、冠状动脉事件发生率及死亡率皆显著低于对照组，两组比较，差异有统计学意义（P＜0.05）。结论阿托伐他汀安全、有效、耐受性好，不良反应少，可作为伴有颈动脉粥样硬化患者的常规用药。
목적：관찰타정류강지약대급만성뇌혈관병적원기료효급졸중재발풍험적영향。방법선취2009년5월～2010년5월아원취진적급만성뇌혈관병환자215례，수궤분위연구조107례급대조조108례，관찰IMT급동맥죽양경화반괴면적적변화급혈지개변、심뇌혈관불량사건발생정황。결과치료조환자치료후여대조조TG、TC、LDL-C급HDL-C비교，차이유통계학의의（P＜0.05）。량조환자12、18、24개월시량조IMT치비교，차이유통계학의의（P＜0.05）；대소유환자수방2년，연구조치사성뇌졸중、비치사성뇌졸중、관상동맥사건발생솔급사망솔개현저저우대조조，량조비교，차이유통계학의의（P＜0.05）。결론아탁벌타정안전、유효、내수성호，불량반응소，가작위반유경동맥죽양경화환자적상규용약。
Objective To evaluate the effects of long term curative effect on acute and chronic cerebral vascular disease and stroke, statins recurrence risk. Methods 215 of acute and chronic cerebral vascular disease patients cases were all collected from May 2009 to May 2010 in our hospital, who were randomly divided into study group 107 cases and control group of 108 patients, all patients were followed up for 2 years, (IMT) changes and blood lipids, atherosclerosis plaque area change and cardiovascular adverse events were all observed. Results Compared two groups of patients with TG, TC, LDL-C and HDL-C after treatment, the diference was signarant(P<0.05). The change of IMT in 12, 18, 24 months of two groups of IMT value comparison, the diference was signarant(P<0.05);The study group of fatal stroke,nonfatal stroke, the incidence of coronary events and mortality were significantly lower than those in the control group (P < 0.05). Conclusion Atorvastatin has safe, effective, well tolerated, and less adverse reaction, can be used as a routine medication in patients with carotid atherosclerosis.