CAJ | 학술논문

目的：观察红花黄色素对犬急性心肌缺血以及血流动力学的影响。方法采用犬冠状动脉结扎心肌缺血动物模型，注射给予红花黄色素，观察其对心肌缺血程度、心肌缺血范围及心肌缺血梗死程度的影响，对血清肌酸激酶及血清乳酸脱氢酶的影响及对血流动力学的影响。结果红花黄色素能减轻心肌缺血程度，降低血清肌酸激酶及乳酸脱氢酶。增加冠脉流量，增加心输出量，对心肌耗氧量无明显影响。结论红花黄色素对犬心肌缺血梗塞具有明显的改善作用。
목적：관찰홍화황색소대견급성심기결혈이급혈류동역학적영향。방법채용견관상동맥결찰심기결혈동물모형，주사급여홍화황색소，관찰기대심기결혈정도、심기결혈범위급심기결혈경사정도적영향，대혈청기산격매급혈청유산탈경매적영향급대혈류동역학적영향。결과홍화황색소능감경심기결혈정도，강저혈청기산격매급유산탈경매。증가관맥류량，증가심수출량，대심기모양량무명현영향。결론홍화황색소대견심기결혈경새구유명현적개선작용。
Objective To evaluate effect of safflor yellow on acute myocardial ischemia and hemodynamics in dogs. Methods The model of myocardial ischemia was induced by ligating coronary artery in dogs. Safflor yellow was administered intravenously .The effects of safflor yellow on the extent and scope of myocardial ischemia,the extent of myocardial infarction,the levels of creatine kinase and lactic acid dehydrogenase in serum and the hemodynamics were examined. Results Safflor yellow could reduce the degree of myocardial ischemia,decrease the activity of creatine kinase and lactic acid dehydrogenase in serum,and increase the coronary flow and cardiac output in dogs.Myocardial oxygen consumption in dogs had no changes. Conclusion Safflor yellow could reduces remarkably the severity of myocardial infarction and improved hemodynamics in dogs.