中华普通外科学文献（电子版）
中華普通外科學文獻（電子版）
중화보통외과학문헌（전자판）
CHINESE JOURNAL OF GENERAL SURGERY(ELECTRONIC VERSION)
2014年
1期
56-60
,共5页
SIRT3%肿瘤代谢再编程%线粒体%去乙酰化酶
SIRT3%腫瘤代謝再編程%線粒體%去乙酰化酶
SIRT3%종류대사재편정%선립체%거을선화매
SIRT3%Reprogramming of tumor metabolism%Mitochondrion%Deacetylase
SIRT3是线粒体内一种重要的去乙酰化酶，对协调线粒体内复杂的代谢反应起关键作用。在抑制肿瘤发生方面，SIRT3通过抗肿瘤代谢再编程保护正常细胞而避免向肿瘤细胞转化和肿瘤发生。SIRT3调节细胞对葡萄糖的摄取，增加细胞抗氧化能力，提高电子传递链中复合体的活性，促进细胞内NADPH的生成，控制能量产生等，从多层次和多角度实现抗肿瘤代谢再编程。这对临床肿瘤诊断和治疗有一定的理论指导，并为肿瘤治疗提供新的策略和方法。
SIRT3是線粒體內一種重要的去乙酰化酶，對協調線粒體內複雜的代謝反應起關鍵作用。在抑製腫瘤髮生方麵，SIRT3通過抗腫瘤代謝再編程保護正常細胞而避免嚮腫瘤細胞轉化和腫瘤髮生。SIRT3調節細胞對葡萄糖的攝取，增加細胞抗氧化能力，提高電子傳遞鏈中複閤體的活性，促進細胞內NADPH的生成，控製能量產生等，從多層次和多角度實現抗腫瘤代謝再編程。這對臨床腫瘤診斷和治療有一定的理論指導，併為腫瘤治療提供新的策略和方法。
SIRT3시선립체내일충중요적거을선화매，대협조선립체내복잡적대사반응기관건작용。재억제종류발생방면，SIRT3통과항종류대사재편정보호정상세포이피면향종류세포전화화종류발생。SIRT3조절세포대포도당적섭취，증가세포항양화능력，제고전자전체련중복합체적활성，촉진세포내NADPH적생성，공제능양산생등，종다층차화다각도실현항종류대사재편정。저대림상종류진단화치료유일정적이론지도，병위종류치료제공신적책략화방법。
SIRT3 is an important deacetylase in the mitochondria, and plays a critical role in coordinating multiple mitochondrial metabolism. With respect to its inhibition of tumor formation, SIRT3 protects normal cells from developing into tumor cells and tumorigenesis through against the reprogramming of tumor metabolism. SIRT3 regulates cells to intake the glucose,improves the ability of defending oxidation and the activities of oxidative phosphorylation complexes, promotes NADPH production and controls the production of energy. So SIRT3 indeed resists the reprogramming of tumor metabolism by multiple mitochondrial processes. This theory that SIRT3 can inhibit the reprogramming of tumor metabolism plays a guiding role in the early detection and treatment of clinical cancer, which will provide new strategies and methods for the treatment of cancer.
