CAJ | 학술논문

目的：分析总结脑转移伴颅外转移患者颅内、颅外多部位放疗的作用，探讨多部位放疗在颅内、颅外多发转移患者治疗中的作用以及与预后的关系。方法：选择第二炮兵总医院2007年7月至2011年10月收治的79例脑转移伴颅外多发转移患者的临床资料进行回顾性分析，所有患者均给予全脑放疗(WBRT)，且在放疗前或放疗后6个月内新发颅外转移灶。52例患者加用立体定向放射治疗(SRS)，其中45例接受颅外转移灶的放射治疗。结果：随访率为97.5%，全组患者中位生存期(MST)为7个月，而单纯颅内放疗组，颅内、颅外多部位放疗组的MST分别为4个月、10个月，两组患者12个月的生存率分别为3%和35%，差异有统计学意义(x2=19.419，P＜0.001)。结论：颅内、颅外多部位多次放疗是脑转移颅外多发转移患者一种有效的治疗手段。
목적：분석총결뇌전이반로외전이환자로내、로외다부위방료적작용，탐토다부위방료재로내、로외다발전이환자치료중적작용이급여예후적관계。방법：선택제이포병총의원2007년7월지2011년10월수치적79례뇌전이반로외다발전이환자적림상자료진행회고성분석，소유환자균급여전뇌방료(WBRT)，차재방료전혹방료후6개월내신발로외전이조。52례환자가용입체정향방사치료(SRS)，기중45례접수로외전이조적방사치료。결과：수방솔위97.5%，전조환자중위생존기(MST)위7개월，이단순로내방료조，로내、로외다부위방료조적MST분별위4개월、10개월，량조환자12개월적생존솔분별위3%화35%，차이유통계학의의(x2=19.419，P＜0.001)。결론：로내、로외다부위다차방료시뇌전이로외다발전이환자일충유효적치료수단。
Objective: To summarize the effect of radiotherapy in the treatment of the brain and extracranial metastases in patients. Analyze and explore the effect of intracranial and extracranial much place radiotherapy in the treatment of patients with brain and extracranial metastases and the relationship between the radiotherapy and prognosis. Methods:From 2007 to 2011,totally 79 patients with brain and extracranial metastases were treated in our center. All patients were given the whole brain radiotherapy (WBRT), WBRT in before or after 6 months new hair extracranial metastases, 52 people were added stereotactic radiotherapy(γ knife). In 45 cases accepted radiotherapy of extracranial metastases. Results: The following-up rate was 97.5%,The median overall survival time was 7 months for the whole group, The median survival time of Simple intracranial radiotherapy group or intracranial extracranial much place radiotherapy group was 4 months or 10 months, x2=19.419, P<0.001, 12 month survival rates respectively was 3%and 35%. Conclusion:Intracranial and extracranial much place radiotherapy is a effectively treatment for patients with brain and extracranial metastases.