CAJ | 학술논문

目的：对临床基因诊断实验室进行优化设计，保障基因扩增检验质量和生物安全，为今后相关实验室的设计改造积累方法和经验。方法：合理改造临床基因诊断实验室的结构，优化设计各实验操作区抽风系统，设置固定各室人员及室间的传递窗。结果：临床基因诊断实验室的优化设计，提高了各实验步骤中样品、模板及试剂等检测结果的准确性，减少了待检标本中传染性病原微生物可能对人员健康和环境产生的危害和污染，保障人员、环境的生物安全。结论：实验室布局合理、使用方便及系统配置完善，可保证基因诊断结果的准确性和安全性。
목적：대림상기인진단실험실진행우화설계，보장기인확증검험질량화생물안전，위금후상관실험실적설계개조적루방법화경험。방법：합리개조림상기인진단실험실적결구，우화설계각실험조작구추풍계통，설치고정각실인원급실간적전체창。결과：림상기인진단실험실적우화설계，제고료각실험보취중양품、모판급시제등검측결과적준학성，감소료대검표본중전염성병원미생물가능대인원건강화배경산생적위해화오염，보장인원、배경적생물안전。결론：실험실포국합리、사용방편급계통배치완선，가보증기인진단결과적준학성화안전성。
Objective: Optimal design of clinical gene diagnosis laboratory, ensure the gene amplification testing quality and protect biological safety, and accumulated a lot of experience and method for the design and improvement of future related laboratory. Methods: By reasonable structural transformation and arrangement to achieve clinical genetic diagnostic laboratories zoning requirements. Relying on the ventilation system of each experiment operating area, each operation achieved a relative buffer zone to form a relatively negative pressure to each chamber airflow unidirectional flow. It achieved a one-way flow of sample templates and reagents through fixed each room staff and setting up room transfer window. Results:Optimal design of clinical genetic diagnostic laboratories improves the accuracy of the test results in the experimental steps about samples, templates, reagents, etc. which easy to be affected by aerosol pollution. It reduces infectious pathogens may cause harm to health of staff and pollution of environment in samples to be tested, and therefore to ensure the accuracy of test results and biological safety of personnel and environmental. Conclusion:By design allows laboratories to achieve a reasonable layout, easy to use, system-equipped to ensure the accuracy of the results of genetic diagnosis and bio-security.