CAJ | 학술논문

目的探讨晚期非小细胞肺癌（NSCLC）组织中肺耐药蛋白（LRP）的表达与铂类化疗耐药及其预后的关系。方法采用免疫组织化学SP法对89例晚期NSCLC碏块进行免疫组织化学染色，检测LRP的表达水平，并分析其与患者的性别、年龄、吸烟史、组织分型、分化程度、远处转移、淋巴结转移及含铂化疗方案疗效的关系。结果在NSCLC患者组织中，LRP的阳性表达率为77.5％，与年龄、吸烟史、组织分型、分化程度和淋巴结转移无关（ P均＞0.05），而LRP表达阳性组和阴性组的含铂类方案化疗疗效、有效率、总反应率、无进展生存时间和总生存时间比较差异无统计学意义（ P均＞0.05）。女性患者肿瘤组织LRP表达阳性率（95.5％）高于男性患者（71.6％）（P＝0.043）；在远处转移的患者中，LPR阳性表达率为87.3％，而无远处转移的患者LRP阳性表达率为61.8％，差异有统计学意义（ P＝0.005）。结论 LRP基因的阳性表达与远处转移有关，且LRP阳性表达患者无疾病进展时间及总生存时间均低于LRP阴性表达患者，提示其可能作为判断预后指标。
목적탐토만기비소세포폐암（NSCLC）조직중폐내약단백（LRP）적표체여박류화료내약급기예후적관계。방법채용면역조직화학SP법대89례만기NSCLC작괴진행면역조직화학염색，검측LRP적표체수평，병분석기여환자적성별、년령、흡연사、조직분형、분화정도、원처전이、림파결전이급함박화료방안료효적관계。결과재NSCLC환자조직중，LRP적양성표체솔위77.5％，여년령、흡연사、조직분형、분화정도화림파결전이무관（ P균＞0.05），이LRP표체양성조화음성조적함박류방안화료료효、유효솔、총반응솔、무진전생존시간화총생존시간비교차이무통계학의의（ P균＞0.05）。녀성환자종류조직LRP표체양성솔（95.5％）고우남성환자（71.6％）（P＝0.043）；재원처전이적환자중，LPR양성표체솔위87.3％，이무원처전이적환자LRP양성표체솔위61.8％，차이유통계학의의（ P＝0.005）。결론 LRP기인적양성표체여원처전이유관，차LRP양성표체환자무질병진전시간급총생존시간균저우LRP음성표체환자，제시기가능작위판단예후지표。
Objective To study the expression of lung resistance protein (LRP) in non-small cell Lung Cancer(NSCLC) and its correlation with Platium resistance and prognosis .Methods The expression of LRP in 89 NSCLC patients was detected by the way of immunohistochemical method .The relationship between LRP and clinico-pathological feature and the others (age, sex, smoking history, histological type, differentiation, distant metastasis, lymphatic metastasis and so on ) were studied .Results In the tissues of patients with NSCLC , the positive express-ing rate of LRP was 77.5%, and was not related with age , sex, smoking history, histological type, differentiation, distant metastasis , lymphatic metastasis ( P>0.05 ) .In the platinum contained chemotherapy regimens , there were not statistical significant difference in RR , DCR, PFS, and OS between the LRP positive expression group and the LRP negative expression group ( all P>0.05 ) .The positive expression rate of LRP in female patients ( 95.5%) was higher than that in male patients(71.6%;P=0.043).The positive expression rate in the patient with distant metas-tasis(87.3%) was higher than that in the patients without distant metastasis (61.8%)(P=0.005).Conclusion The positive expression of LRP is related to the diagnosis distant metastasis of NSCLC .The PFS, OS in LRP-positive patients are lower than those in LRP negative patients .These results suggest LRP may be an evaluating indicator of the prognosis of NSCLC .