CAJ | 학술논문

背景：很多研究都揭示神经干细胞移植是治疗缺血缺氧性脑病的新方法。 　　目的：就神经干细胞移植治疗缺血缺氧性脑病的现状、移植策略以及发挥作用的可能机制等方面做一系统的归纳分析。 　　方法：检索2000年8月至2013年8月PubMed 数据库及中国知网数据库有关神经干细胞移植及缺血缺氧性脑病等方面的文献，英文检索词为“Hypoxic-ischemic encephalopathy，neural stem cel s”，中文检索词为“缺血缺氧性脑病，神经干细胞”。排除与研究目的无关和内容重复者，保留39篇文献做进一步分析。 　　结果与结论：神经干细胞移植能在一定程度上缓解缺血缺氧导致的神经功能的障碍，起到一定的治疗作用，给缺血缺氧性脑病患者带来新希望。但是该研究还处于实验室研究阶段，影响移植的一些关键因素，如：移植途径、时间、单纯或联合移植以及移植的细胞发挥作用的机制等还不明确，还有待科学实验来予以验证。
배경：흔다연구도게시신경간세포이식시치료결혈결양성뇌병적신방법。 　　목적：취신경간세포이식치료결혈결양성뇌병적현상、이식책략이급발휘작용적가능궤제등방면주일계통적귀납분석。 　　방법：검색2000년8월지2013년8월PubMed 수거고급중국지망수거고유관신경간세포이식급결혈결양성뇌병등방면적문헌，영문검색사위“Hypoxic-ischemic encephalopathy，neural stem cel s”，중문검색사위“결혈결양성뇌병，신경간세포”。배제여연구목적무관화내용중복자，보류39편문헌주진일보분석。 　　결과여결론：신경간세포이식능재일정정도상완해결혈결양도치적신경공능적장애，기도일정적치료작용，급결혈결양성뇌병환자대래신희망。단시해연구환처우실험실연구계단，영향이식적일사관건인소，여：이식도경、시간、단순혹연합이식이급이식적세포발휘작용적궤제등환불명학，환유대과학실험래여이험증。
BACKGROUND:Many studies have showed that neural stem cells therapy is a new strategy for hypoxic-ischemic encephalopathy. OBJECTIVE:To review and analyze the status of research, transplantation strategies and mechanism of neural stem cells therapy for treatment of hypoxic-ischemic encephalopathy. METHODS:A computer-based retrieval was performed in PubMed and CNKI database to search papers published from August 2000 to August 2013 using the key words of“hypoxic-ischemic encephalopathy, neural stem cells”in English and Chinese. The papers with objective-independent and repetitive contents were excluded, and final y 39 papers were included for final analysis. RESULTS AND CONCLUSION:Neural stem celltransplantation can promote recovery of neurological function, which brings new hope to hypoxic-ischemic encephalopathy patients. But the study is at a primary stage and limited in laboratory. There are many critical factors that hinder the clinical transplantation, such as delivery path, transplantation time, single or combined transplantation, mechanisms of action. Application of neural stem cells requires further investigation.