中国组织工程研究
中國組織工程研究
중국조직공정연구
Journal of Clinical Rehabilitative Tissue Engineering Research
2014年
1期
137-142
,共6页
干细胞%脂肪干细胞%骨髓干细胞%牙槽骨%生物支架%骨组织工程%骨缺损%骨再生%综述
榦細胞%脂肪榦細胞%骨髓榦細胞%牙槽骨%生物支架%骨組織工程%骨缺損%骨再生%綜述
간세포%지방간세포%골수간세포%아조골%생물지가%골조직공정%골결손%골재생%종술
alveolar bone loss%bone regeneration%dental prosthesis repair%stents
背景:各种生理或病理因素导致的牙槽骨的吸收、缺损是口腔临床医学中的常见问题,但目前较常用的修复缺损牙槽骨的方法不能完全满足临床需要。骨组织工程的出现成为修复骨缺损的研究热点。
<br> 目的:就脂肪干细胞的来源和应用价值、生物支架的种类及特性、生物支架对种子细胞的影响及脂肪干细胞复合支架用于动物实验的研究等方面作一总结。
<br> 方法:应用计算机检索CNKI和Pubmed数据库中1995年1月至2013年4月关于脂肪干细胞、生物支架及骨修复的文章,在标题和中以“脂肪干细胞,分化、增殖和成骨生物支架,牙槽骨,骨组织工程”或“Adipose stem cel s,Differentiation、proliferation and Osteogenesis,Biological scaffold,alveolar bone,bone tissue engineering”为检索词进行检索。选择文章内容与脂肪干细胞和生物支架应用于修复骨缺损有关者,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到163篇文献,根据纳入标准选择关于脂肪干细胞和生物支架应用于修复骨缺损的40篇文献进行综述。
<br> 结果与结论:脂肪干细胞具有与骨髓基质干细胞相似的分化潜能,因其来源广、易采集、易培养低衰老,成骨分化好和风险小等特点被广泛关注,尤其和生物支架应用于骨修复表现出更好的成骨效果。随着有关各科学的发展牙槽骨缺损的修复有关问题都可以解决,脂肪干细胞和生物支架构建工程骨将是实现真正意义上牙槽骨再生的发展趋势且具有良好的发展前景。
揹景:各種生理或病理因素導緻的牙槽骨的吸收、缺損是口腔臨床醫學中的常見問題,但目前較常用的脩複缺損牙槽骨的方法不能完全滿足臨床需要。骨組織工程的齣現成為脩複骨缺損的研究熱點。
<br> 目的:就脂肪榦細胞的來源和應用價值、生物支架的種類及特性、生物支架對種子細胞的影響及脂肪榦細胞複閤支架用于動物實驗的研究等方麵作一總結。
<br> 方法:應用計算機檢索CNKI和Pubmed數據庫中1995年1月至2013年4月關于脂肪榦細胞、生物支架及骨脩複的文章,在標題和中以“脂肪榦細胞,分化、增殖和成骨生物支架,牙槽骨,骨組織工程”或“Adipose stem cel s,Differentiation、proliferation and Osteogenesis,Biological scaffold,alveolar bone,bone tissue engineering”為檢索詞進行檢索。選擇文章內容與脂肪榦細胞和生物支架應用于脩複骨缺損有關者,同一領域文獻則選擇近期髮錶或髮錶在權威雜誌文章。初檢得到163篇文獻,根據納入標準選擇關于脂肪榦細胞和生物支架應用于脩複骨缺損的40篇文獻進行綜述。
<br> 結果與結論:脂肪榦細胞具有與骨髓基質榦細胞相似的分化潛能,因其來源廣、易採集、易培養低衰老,成骨分化好和風險小等特點被廣汎關註,尤其和生物支架應用于骨脩複錶現齣更好的成骨效果。隨著有關各科學的髮展牙槽骨缺損的脩複有關問題都可以解決,脂肪榦細胞和生物支架構建工程骨將是實現真正意義上牙槽骨再生的髮展趨勢且具有良好的髮展前景。
배경:각충생리혹병리인소도치적아조골적흡수、결손시구강림상의학중적상견문제,단목전교상용적수복결손아조골적방법불능완전만족림상수요。골조직공정적출현성위수복골결손적연구열점。
<br> 목적:취지방간세포적래원화응용개치、생물지가적충류급특성、생물지가대충자세포적영향급지방간세포복합지가용우동물실험적연구등방면작일총결。
<br> 방법:응용계산궤검색CNKI화Pubmed수거고중1995년1월지2013년4월관우지방간세포、생물지가급골수복적문장,재표제화중이“지방간세포,분화、증식화성골생물지가,아조골,골조직공정”혹“Adipose stem cel s,Differentiation、proliferation and Osteogenesis,Biological scaffold,alveolar bone,bone tissue engineering”위검색사진행검색。선택문장내용여지방간세포화생물지가응용우수복골결손유관자,동일영역문헌칙선택근기발표혹발표재권위잡지문장。초검득도163편문헌,근거납입표준선택관우지방간세포화생물지가응용우수복골결손적40편문헌진행종술。
<br> 결과여결론:지방간세포구유여골수기질간세포상사적분화잠능,인기래원엄、역채집、역배양저쇠로,성골분화호화풍험소등특점피엄범관주,우기화생물지가응용우골수복표현출경호적성골효과。수착유관각과학적발전아조골결손적수복유관문제도가이해결,지방간세포화생물지가구건공정골장시실현진정의의상아조골재생적발전추세차구유량호적발전전경。
BACKGROUND:Alveolar bone absorption and defect caused by various physiological or pathological factors is a common problem in oral clinical medicine, but the most commonly used methods to repair alveolar bone defects cannot ful y meet clinical needs. The emergence of bone tissue engineering for bone defect repair has become a research hotspot.
<br> OBJECTIVE:To review the source and application of adipose stem cells, the types and characteristics of biological scaffolds, the effect of biological scaffold on seed cells and the application of adipose stem cells composite scaffolds in animal experiment research.
<br> METHODS:A computer-based search of CNKI and PubMed (1995-01/2013-04) was performed to retrieve the related articles about adipose stem cells, biological scaffold and bone repair. The keywords were“adipose stem cells, differentiation, proliferation and osteogenesis, biological scaffold, alveolar bone, bone tissue engineering”in Chinese and English, respectively. Articles published recently or in authorized journals were preferred. There were163 articles after the initial survey. Then, 40 articles were included in result analysis.
<br> RESULTS AND CONCLUSION:Adipose stem cells have a differentiating potential similar to bone marrow stromal stem cells. Adipose stem cells have been widely drawn by variety of sources, easy col ection, easy to cultivate and low aging, good osteogenetic differentiation and low risk. Especial y, adipose stem cells and biological scaffolds used in bone repair show better osteogenesis effect. With the development of science, problems related to alveolar bone defect repair can be solved. Adipose stem cells and biological scaffold for construction of tissue-engineered bone wil be realized in the true sense of the alveolar bone regeneration, with good prospects for development.