CAJ | 학술논문

目的：观察不同剂量甘露聚糖肽胸腔灌注治疗恶性胸腔积液的疗效。方法将从我科住院患者中选取的89例恶性胸腔积液患者随机分为3组，均留置中心静脉导管，胸腔灌注不同剂量的甘露聚糖肽，并进行对比。结果胸腔注入甘露聚糖肽20 mg、40 mg、60 mg的总有效率分别为60．7％、73．3％、80．6％，P＜0．05，有统计学意义。非血性胸腔积液胸腔注入甘露聚糖肽疗效比血性胸腔积液疗效好。不良反应发生率及症状轻重与甘露聚糖肽的剂量无关，患者耐受较好。结论恶性胸腔积液患者胸腔注入较高剂量的甘露聚糖肽较低剂量疗效好，且不增加不良反应的发生率。
목적：관찰불동제량감로취당태흉강관주치료악성흉강적액적료효。방법장종아과주원환자중선취적89례악성흉강적액환자수궤분위3조，균류치중심정맥도관，흉강관주불동제량적감로취당태，병진행대비。결과흉강주입감로취당태20 mg、40 mg、60 mg적총유효솔분별위60．7％、73．3％、80．6％，P＜0．05，유통계학의의。비혈성흉강적액흉강주입감로취당태료효비혈성흉강적액료효호。불량반응발생솔급증상경중여감로취당태적제량무관，환자내수교호。결론악성흉강적액환자흉강주입교고제량적감로취당태교저제량료효호，차불증가불량반응적발생솔。
Objective To investigate the clinical efficacy of different dosage of mannatide for malignant pleural effusion by intrapleural injection .Methods 89 patients with malignant pleural effusion were randomly divided into 3 groups by dosage (20 mg,40 mg,60 mg).All patients underwent thoracic close drainage via central venous catheter and different dosages of man -natide were administrated through the catheter .Results The effective rate was 60.7%,73.3% and 80.6% respectively ( P<0.05).The effective rate in patients with non-bloody pleural effusion was better than that of bloody pleural effusion .Conclusion The effective rate of higher dosage of mannatide in the treatment of malignant pleural effusion is better than that of lower dosage .