CAJ | 학술논문

目的：探讨立体定向放射（ SRT ）联合高强度聚焦超声治疗原发性肝癌的临床价值。方法采用立体定向大分割剂量低分次放疗联合高强度聚焦超声治疗128例原发性肝癌患者，放射生物剂量为DT 60 Gy，同期配合高强度聚焦超声治疗10次。结果近期局部有效率为90．6％；1、2、3年生存率分别为79．7％（102/128）、53．1％（68/128）和46．1％（59/128）；治疗3个月后与治疗前比较，患者血清AFP及CA199水平变化显著（ P＜0．05）；治疗3个月后NK细胞及T淋巴细胞亚群CD3、CD4、CD8、CD4/CD8水平显著提高，治疗前后差异有显著性（ P＜0．01）。结论立体定向低分次放射治疗联合高强度聚焦超声治疗原发性肝癌，能提高肿瘤局部控制率，提高患者机体免疫功能，并减少放射性肝病的发生，是治疗失去手术指征原发性肝癌的有效方法。
목적：탐토입체정향방사（ SRT ）연합고강도취초초성치료원발성간암적림상개치。방법채용입체정향대분할제량저분차방료연합고강도취초초성치료128례원발성간암환자，방사생물제량위DT 60 Gy，동기배합고강도취초초성치료10차。결과근기국부유효솔위90．6％；1、2、3년생존솔분별위79．7％（102/128）、53．1％（68/128）화46．1％（59/128）；치료3개월후여치료전비교，환자혈청AFP급CA199수평변화현저（ P＜0．05）；치료3개월후NK세포급T림파세포아군CD3、CD4、CD8、CD4/CD8수평현저제고，치료전후차이유현저성（ P＜0．01）。결론입체정향저분차방사치료연합고강도취초초성치료원발성간암，능제고종류국부공제솔，제고환자궤체면역공능，병감소방사성간병적발생，시치료실거수술지정원발성간암적유효방법。
Objective To investigate the clinical value of primary hepatic carcinoma treated by hypofractionated ster -eotactic radiotherapy and high-intensity focused ultrasound .Methods 128 patients were treated by stereotactic radiotherapy with total irradiation of DT60Gy and 10 fractions of high-intensity focused ultrasound.Results The local control rate was 90.6% ;1-,2-,and 3-year survival rate was 79.7%(102/128),53.1%( 68/128),46.1%( 59/128) respectively;the changes in ser-um AFP and CA199 before and after treatment were significant (P<0.05);CD3,CD4,CD8,CD4/CD8 and NK cells increased significantly(P<0.01).Conclusion Stereotactic radiotherapy and high-intensity focused ultrasound is an effective treatment for primary hepatic carcinoma .It can ease the symptoms ,control the disease and increase the survival time .