CAJ | 학술논문

目的：探讨血清肿瘤相关物质、糖类抗原12-5对在妇科肿瘤的诊断价值。方法对254例妇科恶性肿瘤、100例妇科良性肿瘤患者及100例健康女性，分别采用电化学发光法、化学比色法测定血清中Ca125、TAM的水平。结果与正常对照组及良性肿瘤组相比，恶性肿瘤患者血清Ca125和TAM的含量明显升高（P＜0．05），Ca125和TAM对妇科恶性肿瘤的检测灵敏度分别为37．4％、44．1％，特异度分别为91．0％、92．5％。两者联合检测灵敏度和特异度分别为67．7％、84．0％。结论血清TAM、Ca125的检测对妇科恶性肿瘤的辅助诊断有重要的意义，两者联合检测可提高妇科恶性肿瘤的检出率，尤其是卵巢癌的检出率。
목적：탐토혈청종류상관물질、당류항원12-5대재부과종류적진단개치。방법대254례부과악성종류、100례부과량성종류환자급100례건강녀성，분별채용전화학발광법、화학비색법측정혈청중Ca125、TAM적수평。결과여정상대조조급량성종류조상비，악성종류환자혈청Ca125화TAM적함량명현승고（P＜0．05），Ca125화TAM대부과악성종류적검측령민도분별위37．4％、44．1％，특이도분별위91．0％、92．5％。량자연합검측령민도화특이도분별위67．7％、84．0％。결론혈청TAM、Ca125적검측대부과악성종류적보조진단유중요적의의，량자연합검측가제고부과악성종류적검출솔，우기시란소암적검출솔。
Objective To investigate the value of serum tumor associated Material ( TAM) and Ca125 in diagnosing gy-necologic tumor .Methods Serum level of Ca125 and TAM in 254 cases of gynecologic malignant tumor ,100 cases of benign tumor and 100 cases of healthy patients were detected by electrochemiluminescence and chemocolorimetry .Results Serum level of Ca125 and TAM in malignant group was significantly higher than that of the benign and healthy group (P<0.05).Sensitivity of TAM and Ca125 in diagnosing malignant tumor were 44.1% and 37.4%, specificity of TAM and Ca125 were 91.0% and 92.5%,combined detection of TAM and Ca 125 in malignant group were 67.7%and 84.0%.Conclusion The combined detec-tion of serum TAM and Ca 125 is helpful to the diagnosis of gynecologic tumor ,especially for the ovarian cancer .