CAJ | 학술논문

目的：探讨进展期胃癌组织中p-ATM、p-p53及p21蛋白表达与化疗疗效及预后的关系。方法采用免疫组化SP法，检测52例进展期胃癌组织中p-ATM、p-p53及p21蛋白表达水平。结果胃癌组织中p-ATM、p-p53及p21阳性表达率分别为36．54％、61．54％、36．54％。52例初治进展期胃癌患者行4个疗程的化疗，p-ATM阳性表达患者治疗有效率最高。生存分析结果提示：p-ATM、p21低表达及p-p53高表达是进展期胃癌患者化疗的不良预后因素。结论进展期胃癌组织中p-ATM、p-p53及p21表达水平与其化疗疗效有关。
목적：탐토진전기위암조직중p-ATM、p-p53급p21단백표체여화료료효급예후적관계。방법채용면역조화SP법，검측52례진전기위암조직중p-ATM、p-p53급p21단백표체수평。결과위암조직중p-ATM、p-p53급p21양성표체솔분별위36．54％、61．54％、36．54％。52례초치진전기위암환자행4개료정적화료，p-ATM양성표체환자치료유효솔최고。생존분석결과제시：p-ATM、p21저표체급p-p53고표체시진전기위암환자화료적불량예후인소。결론진전기위암조직중p-ATM、p-p53급p21표체수평여기화료료효유관。
Objective To explore the relationship of expression of p-ATM,p-p53 and p21 with efficacy and prognosis of chemotherapy for advanced gastric cancer .Methods The expression of p-ATM,p-p53 and p21 in cancer tissues of 52 advanced gastric cancer patients was detected by immunohistochemical method .Results Positive expression rates of p-ATM,p-p53 and p21 in gastric cancer tissues were 36.54%,61.54%and 36.54%,respectively.p-ATM positive patients had the highest effective rate of the 52 advanced gastric cancer patients initially treated with 4 courses of chemotherapy .Survival analysis showed that low level of p-ATM and p21 expression and high level of p-p53 expression were adverse prognostic factors of advanced gastric cancer . Conclusion The expression levels of p-ATM,p-p53 and p21 in advanced gastric cancer are correlated with the efficacy of chem-otherapy .