CAJ | 학술논문

目的：探讨新辅助化疗对乳腺癌激素受体ER、PR表达的影响。方法应用MaxVinsion免疫组织化学技术，检测32例浸润性导管癌乳腺患者新辅助化疗前、新辅助化疗后ER、PR表达情况。结果32例乳腺浸润性导管癌新辅助化疗前与化疗后检测结果完全相同：5例不表达ER，8例ER ＋，12例ER ＋＋，7例ER ＋＋＋；6例不表达PR，7例PR ＋，12例PR ＋＋，7例PR ＋＋＋。同时ER、PR阳性表达具有良好一致性，32例患者中ER、PR阳性表达间具有显著相关性。结论乳腺癌患者新辅助化疗前后激素受体ER、PR表达结果完全一致，新辅助化疗安全可行。
목적：탐토신보조화료대유선암격소수체ER、PR표체적영향。방법응용MaxVinsion면역조직화학기술，검측32례침윤성도관암유선환자신보조화료전、신보조화료후ER、PR표체정황。결과32례유선침윤성도관암신보조화료전여화료후검측결과완전상동：5례불표체ER，8례ER ＋，12례ER ＋＋，7례ER ＋＋＋；6례불표체PR，7례PR ＋，12례PR ＋＋，7례PR ＋＋＋。동시ER、PR양성표체구유량호일치성，32례환자중ER、PR양성표체간구유현저상관성。결론유선암환자신보조화료전후격소수체ER、PR표체결과완전일치，신보조화료안전가행。
Objective To explore the influence of neoadjuvant chemotherapy on the expression of hormone receptors ER、PR in breast cancer .Methods Expression of ER、PR of 32 infitrating ductal carcinoma .patients before and after new adju-vant chemotherapy were detected by Maxvinsion immunohistochemistry .Results Expression of ER、PR of 32 infitrating ductal carcinoma patients before and after new adjuvant chemotherapy were the same .Negative expression of ER was observed in 5,ex-pression of ER +was observed in 8,ER ++in 12 and ER +++in 7.Negative expression of PR was observed in 6,expres-sion of PR +was observed in 7,PR ++in 12 and PR +++in 7.The positive expression of ER and PR was consistent ,and correlation comparison of the positive expression rate of ER and PR was important .Conclusion Expression of hormone receptors ER、PR in breast cancer before and after new adjuvant chemotherapy are the same .Neoadjuvant chemotherapy is safe .