健康研究
健康研究
건강연구
HEALTH RESEARCH
2014年
1期
34-36
,共3页
他克莫司软膏%重组人表皮生长因子凝胶%面部激素依赖性皮炎
他剋莫司軟膏%重組人錶皮生長因子凝膠%麵部激素依賴性皮炎
타극막사연고%중조인표피생장인자응효%면부격소의뢰성피염
Tacrolimus ointment%recombinant human epidermal growth factor gel%hormone dependent facial dermatitis
目的：探讨他克莫司软膏与重组人表皮生长因子凝胶联合治疗面部激素依赖性皮炎的临床疗效，为临床治疗方案的制定提供参考。方法选取我院皮肤科收治的47例面部激素依赖性皮炎的患者，随机数字表法将其分为观察组24例和对照组23例，分别采用他克莫司软膏与重组人表皮生长因子凝胶联合治疗和单纯应用他克莫司软膏治疗。治疗1个月后，对比两组患者的临床疗效、复发率以及不良反应发生情况。结果两组患者治疗后红斑、脱屑、丘疹、脓疱、色素沉着的症状和体征积分均显著低于治疗前（均P＜0．05）；两组总有效率差异没有统计学意义（P＞0．05），但观察组复发率（16．67％）显著低于对照组的52．17％（χ2＝7．823，P＜0．05）；两组患者不良反应的发生率差异无统计学意义（χ2＝0．636，P＞0．05）。结论他克莫司软膏联合重组人生长因子凝胶治疗面部激素依赖性皮炎具有良好的临床疗效，且复发率较低，安全性高，值得在临床上进一步推广应用。
目的：探討他剋莫司軟膏與重組人錶皮生長因子凝膠聯閤治療麵部激素依賴性皮炎的臨床療效，為臨床治療方案的製定提供參攷。方法選取我院皮膚科收治的47例麵部激素依賴性皮炎的患者，隨機數字錶法將其分為觀察組24例和對照組23例，分彆採用他剋莫司軟膏與重組人錶皮生長因子凝膠聯閤治療和單純應用他剋莫司軟膏治療。治療1箇月後，對比兩組患者的臨床療效、複髮率以及不良反應髮生情況。結果兩組患者治療後紅斑、脫屑、丘疹、膿皰、色素沉著的癥狀和體徵積分均顯著低于治療前（均P＜0．05）；兩組總有效率差異沒有統計學意義（P＞0．05），但觀察組複髮率（16．67％）顯著低于對照組的52．17％（χ2＝7．823，P＜0．05）；兩組患者不良反應的髮生率差異無統計學意義（χ2＝0．636，P＞0．05）。結論他剋莫司軟膏聯閤重組人生長因子凝膠治療麵部激素依賴性皮炎具有良好的臨床療效，且複髮率較低，安全性高，值得在臨床上進一步推廣應用。
목적：탐토타극막사연고여중조인표피생장인자응효연합치료면부격소의뢰성피염적림상료효，위림상치료방안적제정제공삼고。방법선취아원피부과수치적47례면부격소의뢰성피염적환자，수궤수자표법장기분위관찰조24례화대조조23례，분별채용타극막사연고여중조인표피생장인자응효연합치료화단순응용타극막사연고치료。치료1개월후，대비량조환자적림상료효、복발솔이급불량반응발생정황。결과량조환자치료후홍반、탈설、구진、농포、색소침착적증상화체정적분균현저저우치료전（균P＜0．05）；량조총유효솔차이몰유통계학의의（P＞0．05），단관찰조복발솔（16．67％）현저저우대조조적52．17％（χ2＝7．823，P＜0．05）；량조환자불량반응적발생솔차이무통계학의의（χ2＝0．636，P＞0．05）。결론타극막사연고연합중조인생장인자응효치료면부격소의뢰성피염구유량호적림상료효，차복발솔교저，안전성고，치득재림상상진일보추엄응용。
Objective To study the clinical effects of Tacrolimus ointment combined with recombinant human epidermal growth factor gel in treating hormone dependent facial dermatitis , so as to obtain scientific knowledge for clinical practice . Method 47 patients suffering hormone dependent facial dermatitis admitted to Quhua Hospital were randomly divided into an experimental group of 24 cases and a control group 23 cases.The experimental group were treated with a combination of Tacrolimus ointment and recombinant human epidermal growth factor gel , while the control group were treated with Tacrolimus ointment only .After one month of treatment , the clinical effects of the medicines on both groups , the recurrence rate and the adverse reaction in both groups were examined and compared .Findings Erythema, desquamation, papules,pustules, pigmentation of the symptoms and signs of integral of the two groups of patients after treatment were found to besignificantly lower than before treatment (P <0.05 ); The total efficiency of two groups were no statistical significance (P >0.05 ), but the recurrence rate of the experimental group (16.67%) was significantly lower than that of the controlgroup ( 52.17% =7.823, P <0.05 ); the incidence rate of adverse reaction in the two groups of patients had nosignificant difference (-x ±s =0.636, P >0.05), and no serious adverse reaction was observed .Conclusion TacrolimusOintment combined with recombinant human growth factor gel can serve as an effective medicine in treating hormonedependent dermatitis, where the recurrence rate is low and safety is high .
