化学分析计量
化學分析計量
화학분석계량
CHEMICAL ANALYSIS AND METERAGE
2014年
1期
57-60
,共4页
张颖卓%崔秀兰%杨庆云%吴松
張穎卓%崔秀蘭%楊慶雲%吳鬆
장영탁%최수란%양경운%오송
草酸艾司西酞普兰%纯度%差示扫描量热法%非水滴定法
草痠艾司西酞普蘭%純度%差示掃描量熱法%非水滴定法
초산애사서태보란%순도%차시소묘량열법%비수적정법
escitalopram oxalate%purity%differetial scanning calorimetry%non-aqueous trirtation method
采用差示扫描量热法（DSC），根据DSC曲线利用纯度分析软件测定草酸艾司西酞普兰的纯度。对实验条件进行了优化，升温速率为4.0 K/min，称样量为2～3.2 mg。测得草酸艾司西酞普兰的纯度为99.17%，相对标准偏差为0.05％(n=6)。该法测定结果与非水滴定法测定结果（99.24％）基本一致。差示扫描量热法可用于测定草酸艾司西酞普兰纯度，方法操作简便、结果准确。
採用差示掃描量熱法（DSC），根據DSC麯線利用純度分析軟件測定草痠艾司西酞普蘭的純度。對實驗條件進行瞭優化，升溫速率為4.0 K/min，稱樣量為2～3.2 mg。測得草痠艾司西酞普蘭的純度為99.17%，相對標準偏差為0.05％(n=6)。該法測定結果與非水滴定法測定結果（99.24％）基本一緻。差示掃描量熱法可用于測定草痠艾司西酞普蘭純度，方法操作簡便、結果準確。
채용차시소묘량열법（DSC），근거DSC곡선이용순도분석연건측정초산애사서태보란적순도。대실험조건진행료우화，승온속솔위4.0 K/min，칭양량위2～3.2 mg。측득초산애사서태보란적순도위99.17%，상대표준편차위0.05％(n=6)。해법측정결과여비수적정법측정결과（99.24％）기본일치。차시소묘량열법가용우측정초산애사서태보란순도，방법조작간편、결과준학。
The differential scanning calorimetry (DSC) technique was used to determine the purity of escitalopram oxalate, according to the DSC curve and by using the purity analysis software. The experimental conditions were optimized, the heating rate was 4.0 K/min and the sample mass was 2-3.2 mg. The purity result determined by DSC method was 99.17%, RSD was 0.05%(n=6). The result was consistent with the result (99.24%) determined by the non-aquseous trirtation method. The DSC method is accurate and simple for the determination of escitalopram oxalate purity.
