CAJ | 학술논문

①目的探讨小剂量重组组织型纤溶酶原激活剂（rt-PA）治疗急性脑梗死的疗效及安全性。②方法发病6h 内的急性脑梗死患者30例，分为溶栓组（16例，接受rt-PA 40mg静脉溶栓治疗）和对照组（14例，未使用rt-PA，其他治疗同溶栓组）。记录治疗前与治疗后2、24h、10d的NIHSS评分及10d时的Barthel指数，并复查头颅CT，进行疗效和安全性评价。③结果两组治疗后 NIHSS 评分较治疗前均有改善，溶栓组较对照组改善更明显，两组比较差异有统计学意义（ P ＜0．05）。溶栓组治疗的总有效率高于对照组（75％、50％， P ＜0．05），溶栓组出现牙龈出血1例，两组均无颅内出血及死亡病例。④结论在严格控制适应证的前提下，小剂量rt-PA治疗急性脑梗死安全有效，优于常规治疗。
①목적탐토소제량중조조직형섬용매원격활제（rt-PA）치료급성뇌경사적료효급안전성。②방법발병6h 내적급성뇌경사환자30례，분위용전조（16례，접수rt-PA 40mg정맥용전치료）화대조조（14례，미사용rt-PA，기타치료동용전조）。기록치료전여치료후2、24h、10d적NIHSS평분급10d시적Barthel지수，병복사두로CT，진행료효화안전성평개。③결과량조치료후 NIHSS 평분교치료전균유개선，용전조교대조조개선경명현，량조비교차이유통계학의의（ P ＜0．05）。용전조치료적총유효솔고우대조조（75％、50％， P ＜0．05），용전조출현아간출혈1례，량조균무로내출혈급사망병례。④결론재엄격공제괄응증적전제하，소제량rt-PA치료급성뇌경사안전유효，우우상규치료。
Objective To evaluate the efficacy and safety of low dose rt -PA in the early treatment of the patients with acute cerebral infarction.Methods 30 patients within 6 hours from the onset of stroke were divided into 2 groups, thrombolytic group(16 cases)and control group(14cases).Patients in thrombolytic group received rt -PA 40mg, patients in control group did not receive thrombolytic therapy .NIHSS and Barthel Index ( BI) were used to evaluate the recovery of neurological functions after rt -PA 2 , 24 hours and 10 days.Cerebral CT were also reexamined .Results The scores of NIHSS after treatment were significantly better than before treatment in the both groups , and the improvement in the thrombolytic group was much greater than control group .The effec-tive rate was higher in thrombolytic group than in control group , There was significant difference between two groups (75%, 50%, P <0.05).There was a patient with gingival bleeding in thrombolytic group .There was no cerebral hemorrhagic complication and mortality in two groups .Conclusion For the individuals with acute cerebral infarction low dose rt -PA thrombolysis was effective and safe within 6h from the symptom onset in case of strict control .It is better than routine treatment .