CAJ | 학술논문

越来越多的研究认为肺癌在其发生及发展过程中表现出异常DNA甲基化模式,5-氮杂-2'-脱氧胞苷是一种DNA甲基转移酶抑制剂,能逆转肺癌DNA甲基化,从而抑制肺癌发生及发展,是目前肺癌治疗研究的新方向.尽管其研究尚处于起步阶段,但有着广阔的前景.文中就5-氮杂-2'-脱氧胞苷在肺癌治疗中的的研究进展进行综述.
월래월다적연구인위폐암재기발생급발전과정중표현출이상DNA갑기화모식,5-담잡-2'-탈양포감시일충DNA갑기전이매억제제,능역전폐암DNA갑기화,종이억제폐암발생급발전,시목전폐암치료연구적신방향.진관기연구상처우기보계단,단유착엄활적전경.문중취5-담잡-2'-탈양포감재폐암치료중적적연구진전진행종술.
More and more studies suggest that the pattern of DNA methylation is abnormal in the occurrence and development of lung cancer.5-aza-2'-deoxycytidine which is a kind of DNA methyltransferase inhibitor can reverse the DNA methylation of lung cancer and inhibit the occurrence and development of lung cancer.This is a new field in the study of lung cancer treatment.Although the research is still in the initial stage,it has a broad prospect.The research advances on 5-aza-2'-deoxycytidine in the treatment of lung cancer are reviewed briefly in this paper.