CAJ | 학술논문

背景丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)是细胞内重要的信号转导系统,在调控神经元可塑性及骨癌痛中发挥重要作用.近年来,发现在中枢和外周神经系统,MAPKs信号通路参与调控了骨癌痛的发生和维持. 目的回顾和总结MAPKs信号通路调控骨癌痛中的机制. 内容 MAPKs家族成员及其上下游信号分子在骨癌痛中的表达及其作用机制. 趋向明晰MAPKs信号系统参与癌痛过程的机制,为更好地治疗肿瘤相关疼痛提供理论依据.
배경 사렬원활화단백격매(mitogen-activated protein kinases,MAPKs)시세포내중요적신호전도계통,재조공신경원가소성급골암통중발휘중요작용.근년래,발현재중추화외주신경계통,MAPKs신호통로삼여조공료골암통적발생화유지. 목적 회고화총결MAPKs신호통로조공골암통중적궤제. 내용 MAPKs가족성원급기상하유신호분자재골암통중적표체급기작용궤제. 추향 명석MAPKs신호계통삼여암통과정적궤제,위경호지치료종류상관동통제공이론의거.
Background Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction system and play vital roles in the regulation of neuronal plasticity and cancer-related pain.In recent years,studies have found that MAPKs regulate bone cancer pain in both central and peripheral nervous system.Objective To retrospect and summarize the mechanism of MAPK signaling pathway in regulating the developing and maintenance of bone cancer pain.Content The expression and the underlying mechanism of MAPK family members and the upstream and downstream signaling molecules in bone cancer pain were reviewed.Trend Clarify the mechanism of MAPKs in cancer pain and provide a theoretical basis for better treatment of cancer-related pain.