CAJ | 학술논문

前列腺凋亡应答蛋白4（Par-4）作为促凋亡因子，最先在雄性激素不依赖型前列腺癌细胞（AT-3）中发现。内源性Par-4使癌细胞对凋亡刺激更敏感化，但是外源性Par-4可选择性地直接导致癌细胞凋亡，并通过基因突变实验发现该活性依赖于它的核心结构域SAC。Par-4和SAC可特异性地导致癌细胞凋亡，因此是潜在的癌症靶点治疗药物。本文综述了Par-4的发现、结构、功能及其在细胞内信号通路，最后讨论了Par-4和SAC在癌症临床治疗中的应用前景以及在基础研究和临床应用中存在的问题。
전렬선조망응답단백4（Par-4）작위촉조망인자，최선재웅성격소불의뢰형전렬선암세포（AT-3）중발현。내원성Par-4사암세포대조망자격경민감화，단시외원성Par-4가선택성지직접도치암세포조망，병통과기인돌변실험발현해활성의뢰우타적핵심결구역SAC。Par-4화SAC가특이성지도치암세포조망，인차시잠재적암증파점치료약물。본문종술료Par-4적발현、결구、공능급기재세포내신호통로，최후토론료Par-4화SAC재암증림상치료중적응용전경이급재기출연구화림상응용중존재적문제。
As a pro-apoptotic factor, prostate apoptosis response protein 4 (par-4) was first found in the male hormone-dependent prostate cells (AT-3). Endogenous Par-4 sensitizes cancer cells to apoptotic stimuli, but exogenous Par-4 selectively induces apoptosis in cancer cells, and these activities depends on the structure of its core domain SAC. Par-4 and SAC can specifically induce apoptosis of cancer cells but not of normal cells, and are therefore potential anti-cancer drugs. In this review we summarize the discovery, structure, and function of par-4, and its intracellular signaling pathways, then discuss the application prospects of Par-4 and SAC in the clinical treatment of cancer and the problems in its research and clinical applications.